| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Vagal afferents sense the peripheral factors and convey these signals to the brain to regulate food intake. In present study, I measured cytosolic Ca^<2+> concentration in the primary cultured neurons of vagal afferents to investigate whether peripheral factor directly act on the vagal afferents. We have found that some of pancreatic and gastrointestinal hormones activate vagal afferents neurons directly. Moreover, the insulin action to vagal afferent neurons was suppressed by ghrelin and potentiated by GLP-1.
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