Research Project
Grant-in-Aid for Young Scientists (B)
I investigated the molecular mechanism of regulation of TASK1 channels in endocrine cells. Pharmacological and molecular biological analyses showed that TASK1 channels are regulated by the clathrin-dependent endocytosis in NGF-stimulated adrenal medullary and PC12 cells. Furthermore, it was suggested that NGF-induced endocytosis of TASK1 channels is regulated by its posttranslational modification through activation of Src and the direct or indirect effects of activation of both PLCγand PI3 kinase.
All 2012 2011 2010
All Journal Article (6 results) Presentation (4 results)
J Pharmacol Sci
Volume: 117(4) Pages: 253-64
10030453700
Cell and Tissue Research
Volume: 344(1) Pages: 41-50
Cancer
Volume: 117(12) Pages: 2735-46
Cell Mol Neurobiol
Volume: 30(8) Pages: 1217-24
J Neurochem
Volume: 114(2) Pages: 617-26
J Histochem Cytochem
Volume: 58(7) Pages: 585-93