Repeated psychological stress induces sexual behavioral impairments

• Project/Area Number: 22790233
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Meijo University
• Principal Investigator: MAMIYA Takayoshi 名城大学, 薬学部, 助教 (70340297)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: コミュニケーションボックス / 心理的ストレス / 性的行動 / 社会性行動 / 豊かな環境 / 性行動 / 豊な環境 / オープンフィールド

Research Abstract

We examined the influences of psychological stress on sexual behaviors using the communication box method in mice. Eight-week old C57BL/6J male mice exposed to stress repeatedly decreased in the numbers of approaches and mounting to females, and showed deficits of social behaviors. Enriched environments for 2 weeks attenuated impairments of sociability but not sexual behaviors.

Research Products

• [Journal Article] Exposure to enriched environments during adolescence prevents abnormal behaviours associated with histone deacetylation in phencyclidine-treated mice (2012)
  • Author(s): Takenao Koseki, Akihiro Mouri, Takayoshi Mamiya, Yuki Aoyama, Kazuya Toriumi, Shizuka Suzuki, Azusa Nakajima, Takuma Yamada, Taku Nagai, and Toshitaka Nabeshima
  • Journal Title: Int. J. Neuropsychopharmacol Volume: (in press)
  • URL: http://dx.doi.org/10.1017/S1461145711001672
  • Peer Reviewed
• [Journal Article] Mouse strain differences in phencyclidine-induced behavioral changes (2012)
  • Author(s): Akihiro Mouri, Takenao Koseki, Shiho Narusawa, Minae Niwa, Takayoshi Mamiya, Shin-ichi Kano, Akira Sawa, and Toshitaka Nabeshima
  • Journal Title: Int. J. Neuropsychopharmacol Volume: 15(6) Pages: 767-79
  • Peer Reviewed
• [Journal Article] Xanthoceraside attenuates amyloid β peptide_<25-35>-induced learning and memory impairments in mice (2012)
  • Author(s): Ping Lu, Takayoshi Mamiya, Lingling Lu, Akihiro Mouri, Takashi Ikejima, Hyung-Chun Kim, Li-Bo Zou, Toshitaka Nabeshima
  • Journal Title: Psychopharmacology(Berl) Volume: 219(1) Pages: 181-90
  • Peer Reviewed
• [Journal Article] Mouse strain differences in phencyclidine-induced behavioral changes (2012)
  • Author(s): Mouri A, et al
  • Journal Title: Int J Neuropsychopharmacol Volume: (In press) Issue: 06 Pages: 767-79
  • DOI: 10.1017/s146114571100085x
  • Peer Reviewed
• [Journal Article] Galantamine attenuates reinstatement of cue-induced methamphetamine-seeking behavior in mice (2012)
  • Author(s): Koseki T, et al
  • Journal Title: Addict Biol Volume: (In press) Issue: 1 Pages: 1-4
  • DOI: 10.1111/j.1369-1600.2011.00425.x
  • Peer Reviewed
• [Journal Article] Xanthoceraside attenuates amyloid β peptide^<25-35>-induced learning and memory impairments in mice (2012)
  • Author(s): Lu P, Mamiya T, Lu L, Mouri A, Ikejima T, Kim HC, Zou LB
  • Journal Title: Psychopharmacology (Berl) Volume: 219(1) Pages: 181-190
  • Peer Reviewed
• [Journal Article] The antidepressant-like effects of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane in mice is related to changes in neuroactive (2012)
  • Author(s): Espallergues J, Mamiya T, Vallee M, Koseki T, Nabeshima T
  • Journal Title: Neuropharmacology Volume: 62(1) Pages: 492-502
  • Peer Reviewed
• [Journal Article] Evaluation of object-based attention in mice (2011)
  • Author(s): Tursun Alkam, Masayuki Hiramatsu, Takayoshi Mamiya, Yuki Aoyama, Atsumi Nitta, Kiyofumi Yamada, Hyoung-Chun Kim, Toshitaka Nabeshima
  • Journal Title: Behav. Brain Res Volume: 220 Pages: 185-193
  • Peer Reviewed
• [Journal Article] Prenatal exposure to PCP produces behavioral deficits accompanied by the overexpression of GLAST in the prefrontal cortex of postpubertal mice (2011)
  • Author(s): Lingling Lu, Takayoshi Mamiya, Ping Lu, Kazuya Toriumi, Akihiro Mouri, Masayuki Hiramatsu, Li-Bo Zou, and Toshitaka Nabeshima
  • Journal Title: Behav. Brain Res Volume: 220 Pages: 132-139
  • Peer Reviewed
• [Journal Article] Evaluation of object-based attention in mice (2011)
  • Author(s): Alkam T, Hiramatsu M, Mamiya T, Aoyama Y, Nitta A, Yamada K, Kim
  • Journal Title: Behav Brain Res Volume: 220(1) Pages: 185-93
  • Peer Reviewed
• [Journal Article] Genetic animal models of schizophrenia related with the hypothesis of abnormal neurodevelopment (2011)
  • Author(s): Lu L, Mamiya T, Koseki T, Mouri A, Nabeshima T
  • Journal Title: Biol Pharm Bull Volume: 34(9) Pages: 1358-1363
  • NAID: 130001872424
  • Peer Reviewed
• [Journal Article] Prenatal exposure to PCP produces behavioral deficits accompanied by the overexpression of GLAST in the prefrontal cortex of postpubertal mice. (2011)
  • Author(s): Lu, Mamiya, et al
  • Journal Title: Behav Brain Res. Volume: 220(1) Pages: 132-139
  • Peer Reviewed
• [Journal Article] Evaluation of object-based attention in mice. (2011)
  • Author(s): Alkam, Hiramatsu, Mamiya, et al
  • Journal Title: Behav Brain Res. Volume: 220(1) Pages: 185-193
  • Peer Reviewed
• [Journal Article] Bi-directional effect of cholecystokinin receptor-2 overexpression on stress-triggered fear memory and anxiety in the mouse (2010)
  • Author(s): Qian Chen, Mingxi Tang, Takayoshi Mamiya, Heh-In Im, Xiaoli Xiong, Anu Joseph, and Ya-Ping Tang
  • Journal Title: PLoS One Volume: 5
  • Peer Reviewed
• [Journal Article] Bi-directional effect of cholecystokinin receptor-2 overexpression on stress-triggered fear memory and anxiety in the mouse. (2010)
  • Author(s): Chen, Tang, Mamiya, et al
  • Journal Title: PLoS One Volume: 5(12)
  • Peer Reviewed
• [Presentation] 妊娠期における温度および日照環境の変化は依存性薬物および遺伝子変異による統合失調症様行動変化に対して脆弱化させる (2012)
  • Author(s): 布目貴大、毛利彰宏、青山雄紀、松本友里恵、鳥海和也、古関竹直、間宮隆吉、澤明、山田清文、鍋島俊隆
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-15
• [Presentation] 心理的ストレスは情動障害を誘発する:コレシキトキニン系の関与 (2012)
  • Author(s): 鶴岡裕生、間宮隆吉、大橋玄季、古関竹直、鳥海和也、毛利彰宏、鍋島俊隆
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-15
• [Presentation] 胎生期におけるフェンサイクリジンの投与は神経前駆細胞の分裂を障害し、前頭前皮質内グルタミン酸作動性神経細胞数の減少を生じる (2012)
  • Author(s): 鳥海和也、毛利彰宏、成澤志穂、青山雄紀、井川夏美、陸玲玲、永井拓、間宮隆吉、鍋島俊隆
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-14
• [Presentation] 幼若期のエンリッチ環境はフェンシクリジン連続投与マウスのヒストンアセチル化に関連した行動異常を予防する (2012)
  • Author(s): 古関竹直、毛利彰宏、間宮隆吉、青山雄紀、鳥海和也、鈴木静香、中島杏紗、山田宅磨、永井拓、鍋島俊隆
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-14
• [Presentation] ガランタミンのメタンフェタミン依存形成抑制作用におけるニコチン性およびムスカリン性アセチルコリン受容体の関与 (2011)
  • Author(s): 古関竹直、毛利彰宏、鈴木静香、中島杏紗、間宮隆吉、鍋島俊隆
  • Organizer: 第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-29
• [Presentation] MAGE-D1 regulates the expression of depressive endophenotypes through ubiquitylation of serotonin transporter (2011)
  • Author(s): Akihiro Mouri, Aya Sasaki, Ken Watanabe, Chiharu Sogawa, Shigeo Kitayama, Takayoshi Mamiya, Yoshiaki Miyamoto, Kiyofumi Yamada, Yukihiro Noda, Toshitaka Nabeshima
  • Organizer: 第32回内藤コンファレンス
  • Place of Presentation: 山梨県北杜市
  • Year and Date: 2011-10-19
• [Presentation] 依存性薬物による精神障害への冬季出産の影響 (2011)
  • Author(s): 布目貴大、毛利彰宏、青山雄紀、鳥海和也、古関竹直、間宮隆吉、鍋島
  • Organizer: 第32回内藤コンファレンス
  • Place of Presentation: 山梨県北杜市
  • Year and Date: 2011-10-19
• [Presentation] メタンフェタミン依存に対するガランタミンの抑制作用 (2011)
  • Author(s): 古関竹直、毛利彰宏、鈴木静香、中島杏紗、間宮隆吉、鍋島俊隆
  • Organizer: 平成23年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-13
• [Presentation] メタンフェタミン依存に対するコレシストキニン2受容体拮抗薬CI-988の抑制作用 (2011)
  • Author(s): 濱みなみ、箕浦由里絵、古関竹直、間宮隆吉、鍋島俊隆
  • Organizer: 平成23年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-13
• [Presentation] Shati遺伝子欠損マウスにおける行動異常と脳内の神経化学的な変化 (2011)
  • Author(s): 本荘龍輝、鳥海和也、渡辺裕之、宋梓瑜、近藤水生、武藤瑛里子、間宮隆吉、新田淳美、福島健、鍋島俊隆
  • Organizer: 平成23年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-13
• [Presentation] 新規薬物依存抑制因子Shati結合タンパク質の探索 (2011)
  • Author(s): 近藤水生、鳥海和也、本荘龍輝、武藤瑛里子、古関竹直、間宮隆吉、永井拓、新田淳美、山田清文、鍋島俊隆
  • Organizer: 平成23年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-13
• [Presentation] 依存性薬物による精神障害への冬季出産の影響 (2011)
  • Author(s): 布目貴大、毛利彰宏、青山雄紀、鳥海和也、古関竹直、間宮隆吉、鍋島俊隆
  • Organizer: 平成23年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-13
• [Presentation] shati遺伝子欠損マウスにおける行動異常と脳内の神経化学的な変化 (2011)
  • Author(s): 本荘龍輝、鳥海和也、渡辺裕之、宋梓瑜、近藤水生、武藤瑛里子、間宮
  • Organizer: 平成23年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-13
• [Presentation] 新規薬物依存抑制因子shati結合タンパク質の探索 (2011)
  • Author(s): 近藤水生、鳥海和也、本荘龍輝、武藤瑛里子、古関竹直、間宮隆吉、永
  • Organizer: 平成23年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-13
• [Presentation] Mouse strain differences in phencyclidine-induced behavioral changes (2011)
  • Author(s): Akihiro Mouri, Takenao Koseki, Shiho Narusawa, Minae Niwa, Takayoshi Mamiya, Shin-ichi Kano, Akira Sawa, Toshitaka Nabeshima
  • Organizer: The 2nd Congress of Asian College of Neuropsyichophamacology
  • Place of Presentation: 韓国ソウル
  • Year and Date: 2011-09-24
• [Presentation] Enriched environment in adolescent prevents abnormal behavior associated with histone deacetylation in phencyclidine-treated mice (2011)
  • Author(s): Takenao Koseki, Akihiro Mouri, Takayoshi Mamiya, Yuki Aoyama, Kazuya Toriumi, Shizuka Suzuki, Azusa Nakajima, Takuma Yamada, Taku Nagai, Toshitaka Nabeshima
  • Organizer: The 2nd Congress of Asian College of Neuropsyichophamacology
  • Place of Presentation: 韓国ソウル
  • Year and Date: 2011-09-24
• [Presentation] Enriched environment in adolescent prevents abnormal behavior associated with histone deacetylation in phencyclidine-treated mice (2011)
  • Author(s): Takeonao Koseki, Akihiro Mouri, Takayoshi Mamiya, Yuki Aoyama
  • Organizer: The 2nd congress of Asian College of Neuropsyichophamacology
  • Place of Presentation: 韓国(ソウル)
  • Year and Date: 2011-09-24
• [Presentation] Mouse strain differences in phencyclidine-induced behavioral changes (2011)
  • Author(s): Akihiro Mouri, Takenao Koseki, Shiho Narusawa, Minae Niwa
  • Organizer: The 2nd congress of Asian College of Neuropsyichophamacology
  • Place of Presentation: 韓国(ソウル)
  • Year and Date: 2011-09-24
• [Presentation] Usp46突然変異マウスが示す尾懸垂行動時間の短縮はGABA系を介する (2011)
  • Author(s): 今井早希、間宮隆吉、鍋島俊隆、海老原史樹文
  • Organizer: 日本動物心理学会・日本動物行動学会・応用動物行動学会・日本家畜管理学会合同学会(Animal2011)
  • Place of Presentation: 東京
  • Year and Date: 2011-09-08
• [Presentation] 新生児期のpoly I : C投与はフェンシクリジン投与によるグルタミン酸作動性神経伝達を障害し、異常行動を増悪させる (2011)
  • Author(s): 毛利彰宏、肥田裕丈、安藤雄、間宮隆吉、永井拓、山田清文、鍋島俊隆、野田幸裕
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-24
• [Presentation] 薬物依存関連分子shati遺伝子欠損マウスにおける行動異常と脳内の生化学的な変化 (2011)
  • Author(s): 渡辺裕之、鳥海和也、宋梓瑜、葛丹、本荘龍輝、毛利彰宏、古関竹直、間宮隆吉、宮本嘉明、新田淳美、福島健、鍋島俊隆
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-23
• [Presentation] フェンサイクリジンによる異常行動に対するクロザピンのエピジェネティックな作用とGABA関連遺伝子発現 (2011)
  • Author(s): 青山雄紀、毛利彰宏、鳥海和也、古関竹直、成澤志穂、井川夏実、間宮隆吉、鍋島俊隆
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-23
• [Presentation] 新生児期のPolyI:C投与はフェンシクリジン投与によるグルタミン酸作動性神経伝達を障害し、異常行動を増悪させる (2010)
  • Author(s): 毛利彰宏、肥田裕丈、安藤雄、永井拓、間宮隆吉、山田清文、鍋島俊隆、野田幸裕
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-03-23
• [Presentation] フェンサイクリジンによる異常行動に対するクロザピンのエピジェネティックな作用とGABA 関連遺伝子発現 (2010)
  • Author(s): 青山雄紀、毛利彰宏、鳥海和也、古関竹直、成澤志穂、間宮隆吉、鍋島俊隆
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-03-23
• [Presentation] 薬物依存関連分子shati遺伝子欠損マウスにおける行動異常と脳内の生化学的な変化 (2010)
  • Author(s): 渡辺裕之、鳥海和也、宋梓瑜、葛丹、本荘龍輝、毛利彰宏、間宮隆吉、古関竹直、宮本嘉明、新田淳美、福島健、鍋島俊隆
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-03-23
• [Book] 我々の内なる狂気,統合失調症は神経生物学的過程である (2011)
  • Author(s): 鍋島俊隆、間宮隆吉
  • Total Pages: 336
  • Publisher: 星和書店
• [Book] 我々の内なる狂気統合失調症は神経生物学的過程である (2011)
  • Author(s): 鍋島俊隆(翻訳)、間宮隆吉, ら
  • Total Pages: 336
  • Publisher: 星和書店