Functional role of FGF21 in the circadian clock regulation
| Project/Area Number |
22790237
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
|
|---|
| Research Institution | National Institute of Advanced Industrial Science and Technology |
|---|
Principal Investigator |
OISHI Katsutaka 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 研究グループ長 (50338688)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 生物時計 / 行動学 / 生理学 / 遺伝子 / 発現制御 |
|---|
| Research Abstract |
To evaluate the functional role of FGF21 in the circadian regulation of physiology and behaviour, we examined the temporal expression profiles of Fgf21 and circadian clock genes in addition to behavioural activity rhythms under ad libitum feeding and time-imposed restricted feeding in mice. The free-running period of locomotor activity rhythm under ALF and the food anticipatory activity under RF remained intact in Fgf21 knockout(KO) mice. Temporal expression profiles of circadian clock genes were essentially identical in peripheral tissues between WT and Fgf21 KO mice. Re-feeding subsequent to transient fasting revealed that re-feeding but not fasting remarkably induces Fgf21 expression in epididymal white adipose tissue.
|
Report
(3 results)
Research Products
(17 results)
