Functional role of FGF21 in the circadian clock regulation

• Project/Area Number: 22790237
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: OISHI Katsutaka 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 研究グループ長 (50338688)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 生物時計 / 行動学 / 生理学 / 遺伝子 / 発現制御

Research Abstract

To evaluate the functional role of FGF21 in the circadian regulation of physiology and behaviour, we examined the temporal expression profiles of Fgf21 and circadian clock genes in addition to behavioural activity rhythms under ad libitum feeding and time-imposed restricted feeding in mice. The free-running period of locomotor activity rhythm under ALF and the food anticipatory activity under RF remained intact in Fgf21 knockout(KO) mice. Temporal expression profiles of circadian clock genes were essentially identical in peripheral tissues between WT and Fgf21 KO mice. Re-feeding subsequent to transient fasting revealed that re-feeding but not fasting remarkably induces Fgf21 expression in epididymal white adipose tissue.

Research Products

• [Journal Article] Circadian mRNA expression of coagulation and fibrinolytic factors is organ-dependently disrupted in aged mice (2011)
  • Author(s): Oishi K, Koyanagi S, Ohkura N
  • Journal Title: Exp Gerontol Volume: 46 Issue: 12 Pages: 994
  • DOI: 10.1016/j.exger.2011.09.003
  • Peer Reviewed
• [Journal Article] Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue (2011)
  • Author(s): K. Oishi, M. Konishi, Y. Murata, N. Itoh
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 412 Issue: 2 Pages: 302-309
  • DOI: 10.1016/j.bbrc.2011.07.125
  • Peer Reviewed
• [Journal Article] PPARγ activation induces acute PAI-1 gene expression in the liver but not in adipose tissues of diabetic model mice (2011)
  • Author(s): Oishi K, Tomita T, Itoh N, Ohkura N
  • Journal Title: Thromb Res Volume: 128 Issue: 5 Pages: e81-e85
  • DOI: 10.1016/j.thromres.2011.06.020
  • Peer Reviewed
• [Journal Article] Thiazolidinediones Are Potent Inducers of Fibroblast Growth Factor 21 Expression in the Liver (2011)
  • Author(s): Oishi K, Tomita T
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 34 Issue: 7 Pages: 1120-1121
  • DOI: 10.1248/bpb.34.1120
  • NAID: 130000738106
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] PPARα deficiency augments a ketogenic diet-induced circadian PAI-1 expression possibly through PPARγ activation in the liver (2011)
  • Author(s): Oishi K, Uchida D, Ohkura N, Horie S
  • Journal Title: Biochem Biophys Res Commun Volume: 401 Issue: 2 Pages: 313
  • DOI: 10.1016/j.bbrc.2010.09.060
  • Peer Reviewed
• [Journal Article] PPARα deficiency augments a ketogenic diet-induced circadian PAI-1 expression possibly through PPARγ activation in the liver. (2010)
  • Author(s): Oishi K, Uchida D, Ohkura N, Horie S
  • Journal Title: Biochem Biophys Res Commun Volume: 401 Pages: 313-318
  • Peer Reviewed
• [Presentation] 食を介した生体リズムの制御 (2012)
  • Author(s): 大石勝隆
  • Organizer: 日本農芸化学会2012年度大会
  • Place of Presentation: 京都女子大学(京都)
  • Year and Date: 2012-03-25
• [Presentation] 食を介した生体リズムの制御 (2012)
  • Author(s): 大石勝隆
  • Organizer: 日本農芸化学会2012年度大会
  • Place of Presentation: 京都、京都女子大学(招待講演)
  • Year and Date: 2012-03-25
• [Presentation] ストレス性睡眠障害モデルマウスの開発とその解析 (2011)
  • Author(s): 宮崎歴、伊藤奈々子、大山純加、大石勝隆
  • Organizer: 第18回日本時間生物学会学術大会
  • Place of Presentation: 名古屋大学(愛知)
  • Year and Date: 2011-11-24
• [Presentation] ストレス性睡眠障害モデルマウスにおける耐糖能異常 (2011)
  • Author(s): 大山純加、伊藤奈々子、宮崎歴、大石勝隆
  • Organizer: 第18回日本時間生物学会学術大会
  • Place of Presentation: 名古屋大学(愛知)
  • Year and Date: 2011-11-24
• [Presentation] ストレス性睡眠障害モデルマウスにおける耐糖能異常 (2011)
  • Author(s): 大山純加、伊藤奈々子、宮崎歴、大石勝隆
  • Organizer: 第18回日本時間生物学会学術大会
  • Place of Presentation: 愛知、名古屋大学
  • Year and Date: 2011-11-24
• [Presentation] ストレス性睡眠障害モデルマウスの開発とその解析 (2011)
  • Author(s): 宮崎歴、伊藤奈々子、大山純加、大石勝隆
  • Organizer: 第18回日本時間生物学会学術大会
  • Place of Presentation: 愛知、名古屋大学
  • Year and Date: 2011-11-24
• [Presentation] マウス食餌中の脂肪酸組成の差異が血管内皮細胞の抗血栓性機能に及ぼす機能 (2011)
  • Author(s): 堀江修一、平石さゆり、梶村佳世、平岡真実、大石勝隆
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都国際会館(京都)
  • Year and Date: 2011-09-23
• [Presentation] マウス食餌中の脂肪酸組成の差異が血管内皮細胞の抗血栓性機能に及ぼす機能 (2011)
  • Author(s): 堀江修一、平石さゆり、梶村佳世、平岡真実、大石勝隆
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都、京都国際会館
  • Year and Date: 2011-09-23
• [Presentation] 慢性ストレス性睡眠障害モデルマウスの開発と評価 (2011)
  • Author(s): 宮崎歴、伊藤奈々子、大蔵直樹、大石勝隆
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-09-15
• [Presentation] 慢性ストレス性睡眠障害モデルマウスの開発と評価 (2011)
  • Author(s): 宮崎歴、伊藤奈々子、大蔵直樹、大石勝隆
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 神奈川、パシフィコ横浜
  • Year and Date: 2011-09-15
• [Presentation] 食を介した生体リズムの制御と睡眠の改善を目指して (2010)
  • Author(s): 大石勝隆
  • Organizer: 第17回日本時間生物学会学術大会
  • Place of Presentation: 早稲田大学・国際会議場・井深大記念ホール(東京)
  • Year and Date: 2010-11-20