| Project/Area Number |
22790238
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
UCHIDA Sae 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (90270660)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ストレス / 卵巣ホルモン / 交感神経 / 卵胞 / 黄体 / ラット |
|---|
| Research Abstract |
Involvement of sympathetic nerve hyperactivity in stress-induced ovarian dysfunction was examined in rats. Acute stress(nociceptive cutaneous stimulation) reduced the ovarian estradiol secretion rate via activation of the superior ovarian nerve. The reduction of estradiol secretion by superior ovarian nerve activation was caused by inhibition of testosterone conversion into estradiol. Chronic stress, which caused sympathetic nerve hyperactivation, produced morphological changes in the ovarian tissues(increase in the number of cystic follicles and decrease in the number of corpus luteum), suggesting an ovulatory dysfunction.
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