The role of opioid neurotransmission in pain-induced aversion
Project/Area Number |
22790239
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
General pharmacology
|
Research Institution | Hokkaido University |
Principal Investigator |
IDE Soichiro 北海道大学, 大学院・薬学研究院, 助教 (30389118)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 痛み / 嫌悪 / 不安 / 食欲 / 分界条床核 / オピオイド / ノルアドレナリン / 不快情動 / 条件付け場所嫌悪性試験 / μオピオイド受容体 / DAMGO |
Research Abstract |
In the present study, we examined the role of the opioid within the bed nucleus of the stria terminalis(BNST) in pain-induced aversion. The conditioned place aversion(CPA) induced by intra-dorsolateral part of BNST(dlBNST) injection of CRF was reversed by the co-injection of an opioid agonist. On the other hand, nociceptive behaviors induced by pain stimulus were also changed by intra-dlBNST injection of opioid agonist. Further, we revealed that noradrenergic transmission within the ventral part of BNST regulates food intake and anxiety-like behaviors.
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Report
(3 results)
Research Products
(11 results)