Clarification of the mechanism of a novel inhibitory effect on platelet aggregation via prostaglandin E_2 receptor
| Project/Area Number |
22790241
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 心血管 / 血液 / 血小板 / プロスタグランジンE2 / EP2受容体 / EP4受容体 / 受容体欠損マウス / プロスタグランジンE_2 / EP_2受容体 / EP_4受容体 |
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| Research Abstract |
In this study, it was suggested that selective activation of prostaglandin E_2 receptor subtype EP_2 or EP4 showed the inhibitory effect on platelet aggregation. Notably, an EP_4 agonist can inhibit human platelet aggregation with high potency, suggesting a potential of EP_4 agonists as novel anti-platelet agents.
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Report
(3 results)
Research Products
(13 results)
