Functional significance of astrocytic calcium signal-dependent regulation of translational repressor
Project/Area Number |
22790243
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
General pharmacology
|
Research Institution | The University of Tokyo |
Principal Investigator |
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 神経-グリア相互作用 / アストロサイト / カルシウムシグナル / 神経保護作用 / カドヘリン / 翻訳抑制因子 / 神経・グリア相互作用 |
Research Abstract |
The functional significance of astrocytes remains ununderstood. Current study revealed that brain injury-induced calcium signaling in astrocytes contributes to the formation of reactive astrocytes and neuroprotective role of astrocytes via the regulation of translational repressor pumilio-2 and cell adhesion protein N-cadherin.
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Report
(3 results)
Research Products
(13 results)