Transcriptome analysis of anti-metabolic syndrome effects of Nicaraven

• Project/Area Number: 22790248
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General pharmacology
• Research Institution: Mie University
• Principal Investigator: SHIMADA Yasuhito 三重大学, 大学院・医学系研究科, 助教 (40378427)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 内臓脂肪 / 肥満 / ゼブラフィッシュ / ヘムオキシゲナーゼ / ヘムオキシゲナーゼ1

Research Abstract

Nicaraven(NIC) is a multifunctional prodrug including antioxidant activity with HMOX1 induction. It has been reported that HMOX1 could improve insulin resistance of obesity model of rat. In this study, we demonstrated that NIC ameliorated metabolic syndrome of diet-induced obesity model of zebra fish. The transcriptome analysis revealed the therapeutic mechanism of NIC-HMOX1 axis.

Research Products

• [Journal Article] A novel protocol for the oral administration of test chemicals to adult zebrafish (2011)
  • Author(s): Zang L, Morikane D, Shimada Y, Tanaka T, Nishimura N
  • Journal Title: Zebrafish Volume: Vol.8 Pages: 203-220
  • NAID: 120005228797
  • Peer Reviewed
• [Journal Article] Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model (2011)
  • Author(s): Tainaka T, Shimada Y, Kuroyanagi J, Zang L, Oka T, Nishimura Y, Nishimura N, Tanaka T
  • Journal Title: Nutrition & Metabolism Volume: Vol.8 Pages: 88-88
  • Peer Reviewed
• [Journal Article] オミックス創薬科学とターゲットバリデーション (2011)
  • Author(s): 田中利男、西村有平、島田康人
  • Journal Title: 臨床薬理 Volume: 42巻 Pages: 169-170
  • NAID: 10029432866
• [Journal Article] Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity (2010)
  • Author(s): Oka T, Nishimura Y, Zang L, Hirano M, Shimada Y, Wang Z, Umemoto N, Kuroyanagi J, Nishimura N, Tanaka T
  • Journal Title: BMC physiology Volume: Vol.10 Pages: 21-21
  • Peer Reviewed
• [Journal Article] Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity. (2010)
  • Author(s): Oka T, Nishimura Y, Zang L, Hirano M, Shimada Y, Wang Z, Umemoto N, Kuroyanagi J, Nishimura N, Tanaka T.
  • Journal Title: BMC physiology Volume: 10(published online) Pages: 21-21
  • Peer Reviewed
• [Presentation] 食餌性肥満ゼブラフィッシュによる機能性食品の薬理ゲノミクス研究 (2011)
  • Author(s): 島田康人、田井中俊行、黒柳淳哉、臧黎清、西村有平、西村訓弘、田中利男
  • Organizer: 第120回日本薬理学会近畿部会
  • Year and Date: 2011-11-11
• [Presentation] ゼブラフィッシュによるオミックス医学スクリーニングシステム (2011)
  • Author(s): 田中利男、西村有平、島田康人、梅本紀子、黒柳淳哉
  • Organizer: 第12回モレキュラーデバイステクニカルセミナー
  • Year and Date: 2011-06-21
• [Presentation] オミックス創薬科学とターゲットバリデーション (2010)
  • Author(s): 田中利男、西村有平、島田康人
  • Organizer: 第31回日本臨床薬理学会
  • Year and Date: 2010-12-03
• [Presentation] オミックス創薬・創食を実現するゼブラフィッシュモデルシステム開発 (2010)
  • Author(s): 田中利男、島田康人、西村有平
  • Organizer: 第9回国際バイオEXPO
  • Year and Date: 2010-06-30