A New Approach to Searching for the Bioactive Molecules Regulating Potassium Channel
| Project/Area Number |
22790250
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 内向き整流性カリウムチャネル / ファーマコフォア / スフィンゴ脂質 / 電気生理学 / 薬理学 / 電位依存性カリウムチャネル / 脂質 |
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| Research Abstract |
This study aimed to explore a novel bioactive molecule that regulate ion channel function by in silico screening with a pharmacophore model of its chemical ligands. Sphingosine fits the pharmacophore model for inwardly rectifier potassium(Kir) channel 4. 1 blockers. Sphingosine has an inhibitory effect on Kir4. 1 channels. When biosynthesis of sphingosine from sphingomyeline via ceramide is stimulated, Kir4. 1 channel currents decrease. These results suggest that endogenous sphingolipids inhibit Kir4. 1 channels via sphingosine.
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Report
(3 results)
Research Products
(35 results)
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[Journal Article] Ca^<2+> entry mode of Na^+/ Ca^<2+> exchanger as a new therapeutic target for heart failure with preserved ejection fraction2012
Author(s)
Daisuke Kamimura, Tomohito Ohtani, Yasushi Sakata, Toshiaki Mano, Yasuharu Takeda, Shunsuke Tamaki, Yosuke Omori, Yasumasa Tsukamoto, Kazuharu Furutani, Yutaka Komiyama, Masamichi Yoshika, Hakuo Takahashi, Toshio Matsuda, Akemichi Baba, Satoshi Umemura, Takeshi Miwa, Issei Komuro, Kazuhiro Yamamoto
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Journal Title
European Heart Journal
Volume: (in press)
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Peer Reviewed
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[Presentation] 薬物のhERGチャネル機能制御2010
Author(s)
古谷和春、稲野辺厚、山川祐子、岩田美紀、倉智嘉久
Organizer
平成22年度筋生理の集い(招待講演)
Place of Presentation
東京慈恵会医科大学高木会館(東京都)
Year and Date
2010-12-04
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