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A study on the anti-obesity function of an adipokine, D-dopachrome tautomerase

Research Project

Project/Area Number 22790253
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionThe University of Tokushima

Principal Investigator

IWATA Takeo  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (10350399)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsアディポカイン / 肥満 / 脂肪組織 / インスリン抵抗性 / 脂質代謝 / 脂肪分解 / 脂肪細胞 / AMPK / ホルモン感受性リパーゼ / アセチルCoAカルボキシラーゼ
Research Abstract

D-dopachrome tautomerase whose mRNA levels are decreased in obese adipocytes acts to regulate contents of triacylglycerol in adipocytes. In this study, DDT was found to regulate expression and activity of molecules involved in lipid metabolism in adipocytes. Furthermore, administration of DDT improved the glucose intolerance in obese mice. These results suggested that DDT acts as an adipokine with anti-obese property.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (11 results)

All 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (9 results)

  • [Journal Article] Vimentin binds IRAP and is involved in GLUT4 vesicle trafficking2011

    • Author(s)
      H irata Y, Iwata T, Le CTH, Jambaldorj B, Teshigawara K, Harada N, Sakaue H, Sakai T, Yoshimoto K, Nakaya Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 405(1) Issue: 3 Pages: 96-101

    • DOI

      10.1371/journal.pone.0033402

    • NAID

      120006631415

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vimentin binds IRAP and is involved in GLUT4 vesicle trafficking.2011

    • Author(s)
      Hirata Y, et al
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 405(1) Issue: 1 Pages: 96-101

    • DOI

      10.1016/j.bbrc.2010.12.134

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] D-dopachrome tautomeraseは肥満マウスでのインスリン抵抗性を改善する2011

    • Author(s)
      岩田武男
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Year and Date
      2011-10-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] D-dopachrome tautomeraseは脂肪細胞での脂質代謝を制御する2011

    • Author(s)
      岩田武男
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌プリンスホテル(北海道)
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] D-dopachrome tautomeraseは肥満マウスでのインスリン抵抗性を改善する2011

    • Author(s)
      岩田武男
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Related Report
      2011 Final Research Report
  • [Presentation] D-dopachrome tautomeraseは脂肪細胞での脂質代謝を制御する2011

    • Author(s)
      岩田武男
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌プリンスホテル(札幌市)
    • Related Report
      2011 Final Research Report
  • [Presentation] D-dopachrome tautomeraseは脂肪細胞での中性脂肪量を制御する2010

    • Author(s)
      岩田武男
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 持続的圧縮力は前駆脂肪細胞からの脂肪細胞への分化を抑制する2010

    • Author(s)
      岩田武男
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functional analysis of a novel adipokine, D-dopachrome tautomerase, in preadipocytes2010

    • Author(s)
      石本恭子
    • Organizer
      International Joint Symposium : The University of Tokushima, Universitas Gadjah Mada, Niigata University
    • Place of Presentation
      The Patra Bali(インドネシアバリ)
    • Related Report
      2011 Final Research Report
  • [Presentation] D-dopachrome tautomeraseは脂肪細胞での中性脂肪量を制御する2010

    • Author(s)
      岩田武男
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2011 Final Research Report
  • [Presentation] D-dopachrome tautomeraseが脂肪分化に及ぼす影響2010

    • Author(s)
      石本恭子
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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