A study on the anti-obesity function of an adipokine, D-dopachrome tautomerase
Project/Area Number |
22790253
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
General pharmacology
|
Research Institution | The University of Tokushima |
Principal Investigator |
IWATA Takeo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (10350399)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | アディポカイン / 肥満 / 脂肪組織 / インスリン抵抗性 / 脂質代謝 / 脂肪分解 / 脂肪細胞 / AMPK / ホルモン感受性リパーゼ / アセチルCoAカルボキシラーゼ |
Research Abstract |
D-dopachrome tautomerase whose mRNA levels are decreased in obese adipocytes acts to regulate contents of triacylglycerol in adipocytes. In this study, DDT was found to regulate expression and activity of molecules involved in lipid metabolism in adipocytes. Furthermore, administration of DDT improved the glucose intolerance in obese mice. These results suggested that DDT acts as an adipokine with anti-obese property.
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Report
(3 results)
Research Products
(11 results)