A potential treatment of glaucoma by glia-derived lipoproteins.

• Project/Area Number: 22790254
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General pharmacology
• Research Institution: Kumamoto University
• Principal Investigator: HAYASHI Hideki 熊本大学, 大学院・先導機構, 特任助教 (90508657)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 緑内障 / リポプロテイン / グリア細胞

Research Abstract

Glaucoma is the leading cause of blindness in Japan. Thus, the aims of this study are to analyze mechanisms of developing glaucoma and neuroprotection by glia-derived lipoproteins. Glaucoma induces degeneration of retinal ganglion cells(RGCs), so we determined whether lipoproteins were able to protect primary cultured RGCs from degeneration induced by glutamate. This study demonstrated that lipoproteins protected RGCs from apoptosis by preventing calcium overload.

Research Products

• [Journal Article] 中枢神経系の脂質代謝と神経変性疾患 (2011)
  • Author(s): 林秀樹
  • Journal Title: 日本薬理学雑誌 Volume: 137 Pages: 227-231
  • NAID: 10029417699
• [Journal Article] Lipid metabolism and glial lipoproteins in the central nervous system (2011)
  • Author(s): Hayashi, H.
  • Journal Title: Biol Pharm Bull Volume: 34 Pages: 453-461
  • Peer Reviewed
• [Journal Article] Dynamic imaging of axonal transport in living retinal ganglion cells in vitro (2011)
  • Author(s): Takihara, Y., Inatani, M., Hayashi, H., Adachi, N., Iwao, K., Inoue, T., Iwao, M., and Tanihara, H.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52 Pages: 3039-3045
  • Peer Reviewed
• [Journal Article] Dynamic imaging of axonal transport in living retinal ganglion cells in vitro (2011)
  • Author(s): Takihara, Y
  • Journal Title: Invest Ophthalmol Vis Sci Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Formation and function of apolipoprotein E-containing lipoproteins in the nervous system (2010)
  • Author(s): Vance, J. E., and Hayashi, H.
  • Journal Title: Biochim Biophys Acta Volume: 1801 Pages: 806-818
  • Peer Reviewed
• [Presentation] Low density lipoprotein receptor-related protein-1 mediates the neuroprotection of apolipoprotein E-containing lipoproteins against glutamate neurotoxicity (2012)
  • Author(s): Hayashi H.
  • Organizer: Jpn. J. Pharmacol.第85回日本薬理学会年会
  • Place of Presentation: 京都国際会館(京都)
  • Year and Date: 2012-03-15
• [Presentation] Low density lipoprotein receptor-related protein-1 mediates the neuroprotection of apolipoprotein E-containing lipoproteins against glutamate neurotoxicity (2012)
  • Author(s): HAYASHI, Hideki
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2012-03-15
• [Presentation] Protection from neurodegeneration by apolipoprotein E-containing lipoproteins (2011)
  • Author(s): Hayashi H.
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都国際会館(京都)
  • Year and Date: 2011-09-23
• [Presentation] Protection from neurodegeneration by apolipoprotein E-containing lipoproteins (2011)
  • Author(s): HAYASHI, Hideki
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都国際会館(京都府)(招待講演)
  • Year and Date: 2011-09-23
• [Presentation] Protection of neurons from apoptosis by apolipoprotein E-containing lipoproteins(Neuro2010) (2010)
  • Author(s): Hayashi H., Vance J. E.
  • Organizer: 第53回日本神経化学会年会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2010-09-02
• [Presentation] アポリポプロテインE含有リポプロテインのアポトーシスに対する神経細胞保護 (2010)
  • Author(s): 林秀樹
  • Organizer: 第53回日本神経化学会大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-09-02
• [Book] Oxford University Press, Lipids, lipid mediators and other signaling molecules. Neuroglia, 3rd Edition (2012)
  • Author(s): Hayashi H
• [Remarks]
  • URL: http://sendou.kuma-u.jp/research/hayashi.html
• [Remarks]
  • URL: http://sendou.kuma-u.jp/research/hayashi.html
• [Remarks]
  • URL: http://sendou.kuma-u.jp/research/hayashi.html
• [Patent(Industrial Property Rights)] リポ蛋白含有複合体およびリポ蛋白を用いた神経変性抑制剤ならびに神経変性抑制方法 (2011)
  • Inventor(s): 林秀樹
  • Industrial Property Rights Holder: 熊本大学、東京医科歯科大学
  • Industrial Property Number: 2011-205390
  • Filing Date: 2011-09-20