Hydrogen sulfide protects insulin-secreting cells from cell damage-Characterization of the cytoprotective effects and the molecular mechanisms-

• Project/Area Number: 22790255
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General pharmacology
• Research Institution: Oita University
• Principal Investigator: TANIGUCHI Shigeki 大分大学, 医学部, 助教 (90392406)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 生理活性物質 / 細胞保護作用 / 膵B細胞 / 薬理学 / 糖尿病 / 硫化水素 / ガス性メッセンジャー

Research Abstract

The aim of this study is to characterize the cytoprotective effects of a gasotransmitter hydrogen sulfide(H_2S) and to elucidate its molecular mechanism on insulin-secreting cells. H_2S, which is endogenously produced in an inducible manner by H_2S-producing enzyme CSE, protects insulin-secreting cells against oxidative stress(occur under diabetic condition) via an anti-oxidative mechanism.

Research Products

• [Journal Article] Protein phosphorylation involved in the gene expression of the hydrogen sulphide producing enzyme cystathionineγ-lyase in the pancreaticβ-cell (2012)
  • Author(s): Shigeki Taniguchi, Toshihide, Kimura, Tatsuhito Umeki, 省略7名
  • Journal Title: Molecular and Cellular Endocrinology Volume: 350 Pages: 31-38
  • Peer Reviewed
• [Journal Article] Protein phosphorylation involved in the gene expression of the hydrogen sulphide producing enzyme cystathionine γ-lyase in the pancreatic β-cell (2012)
  • Author(s): Taniguchi S, Kimura T, Umeki T, Kimura Y, Kimura H, Ishii I, Itoh N, Naito Y, Yamamoto H, Niki I
  • Journal Title: Mol.Cell.Endocrinol. Volume: 350 Issue: 1 Pages: 31-38
  • DOI: 10.1016/j.mce.2011.11.016
  • Peer Reviewed
• [Journal Article] Significance of hydrogen sulfide production in the pancreaticβ-cell (2011)
  • Author(s): Shigeki Taniguchi, Ichiro Niki
  • Journal Title: Journal of Pharmacological Sciences Volume: 116 Pages: 1-5
  • Peer Reviewed
• [Journal Article] Hydrogen sulphide protects mouse pancreaticβ-cells from cell death induced by oxidative stress, but not by endoplasmic reticulum stress (2011)
  • Author(s): Shigeki Taniguchi, Lin Kang, Toshihide Kimura, 省略1名
  • Journal Title: British Journal of Pharmacology Volume: 162 Pages: 1171-1178
  • Peer Reviewed
• [Journal Article] Significance of hydrogen sulfide production in the pancreatic β-cell (2011)
  • Author(s): Shigeki Taniguchi, Ichiro Niki
  • Journal Title: Journal of Pharmacological Sciences Volume: 116 Pages: 1-5
  • NAID: 10029893605
  • Peer Reviewed
• [Journal Article] Hydrogen sulphide protects mouse pancreatic β-cells from cell death induced by oxidative stress, but not by endoplasmic reticulum stress (2011)
  • Author(s): Shigeki Taniguchi, Lin Kang, Toshihide Kimura, Ichiro Niki
  • Journal Title: British Journal of Pharmacology Volume: VOL.162 Pages: 1171-1178
  • Peer Reviewed
• [Presentation] マウス膵β細胞における硫化水素産生酵素のカルシウム依存性発現調節 (2012)
  • Author(s): 谷口繁生
  • Organizer: 第85回日本薬理学会
  • Place of Presentation: 京都府京都市
  • Year and Date: 2012-03-15
• [Presentation] マウス膵β細胞における硫化水素産生酵素のカルシウム依存性発現調節 (2012)
  • Author(s): 谷口繁生、木村俊秀、岡本光弘、仁木一郎
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都府京都市
  • Year and Date: 2012-03-15
• [Presentation] 膵島における硫化水素産生酵素の発現調節の種差について (2011)
  • Author(s): 谷口繁生
  • Organizer: 第64回日本薬理学会西南部会
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2011-11-20
• [Presentation] 硫化水素が膵B細胞を保護する分子機序の検討 (2011)
  • Author(s): 谷口繁生
  • Organizer: 第54回日本糖尿病学会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2011-05-20
• [Presentation] 酸化ストレス抑制により硫化水素はマウス膵β細胞を保護する (2011)
  • Author(s): 谷口繁生
  • Organizer: 第84回日本薬理学会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2011-03-22
• [Presentation] 酸化ストレス抑制により硫化水素はマウス膵β細胞を保護する (2011)
  • Author(s): 谷口繁生
  • Organizer: 日本薬理学会
  • Place of Presentation: パシフィコ横浜(神奈川県)(学会中止により誌上発表)
  • Year and Date: 2011-03-22
• [Presentation] 硫化水素によるマウス膵β細胞保護作用の特性について (2010)
  • Author(s): 谷口繁生
  • Organizer: 第53回日本糖尿病学会
  • Place of Presentation: 岡山県岡山市
  • Year and Date: 2010-05-28
• [Presentation] 硫化水素によるマウス膵β細胞保護作用の特性について (2010)
  • Author(s): 谷口繁生
  • Organizer: 日本糖尿病学会
  • Place of Presentation: 岡山市デジタルミュージアム(岡山県)
  • Year and Date: 2010-05-28