Hydrogen sulfide protects insulin-secreting cells from cell damage-Characterization of the cytoprotective effects and the molecular mechanisms-
Project/Area Number |
22790255
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
General pharmacology
|
Research Institution | Oita University |
Principal Investigator |
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 生理活性物質 / 細胞保護作用 / 膵B細胞 / 薬理学 / 糖尿病 / 硫化水素 / ガス性メッセンジャー |
Research Abstract |
The aim of this study is to characterize the cytoprotective effects of a gasotransmitter hydrogen sulfide(H_2S) and to elucidate its molecular mechanism on insulin-secreting cells. H_2S, which is endogenously produced in an inducible manner by H_2S-producing enzyme CSE, protects insulin-secreting cells against oxidative stress(occur under diabetic condition) via an anti-oxidative mechanism.
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Report
(3 results)
Research Products
(14 results)