| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
I revealed that vasodilator responsesof retinal blood vesselsmediated through the mechanism via activation ofendothelial cells, but not those to direct stimulation of smooth muscle, was attenuated in the rat models of glaucoma, which was inducedby retinal ischemia-reperfusionorintravitreal injection of N-methyl-D-aspartic acid. These results suggested that abrormal retinal circulation in glaucoma may accelerateretinal degeneration. It was also suggested that endothelin-1 played an important role to induce severe constriction of theretinal vasculature in the ischemia-reperfusion model. Anagonist of prostanoid EP2 receptor dilatedretinal bloodvessels in the glaucoma model rats, as in the normal rats and inhibited the retinal nerve injury. These results suggestthat prostanoid EP2 receptor agonistsmay be novel candidate drugsfor prevention and/or treatment of glaucoma.
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