| Project/Area Number |
22790262
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | Toho University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
TANAKA Hikaru 東邦大学, 薬学部, 教授 (40236617)
TAKAHARA Akira 東邦大学, 薬学部, 准教授 (80377481)
KAWANISHI Toru 国立衛生試験所, 部長 (40124383)
TANAKA Naoko 大妻女子大学, 家政学部, 教授 (40184353)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 薬理学 / 肺静脈心筋 / カルシウムイメージング / 自動能 / 心房細動 / カルシウム / イメージング |
|---|
| Research Abstract |
We assessed the electrophysiological properties of pulmonary vein myocardium and analyzed its arrhythmogenic activity. Some of the pulmonary vein cardiomyocytes, but not atrial cardiomyocytes, showed sustained spontaneous Ca2+transients. But morphology and the sarcoplasmic reticulum content of pulmonary vein cardiomyocytes were the same as those of atrial myocytes. The pulmonary vein myocardium had a less negative resting membrane potential and lower density of inwardly rectifying potassium current than atrial. These results suggest that the lower density of repolarizing currents in pulmonary vein cardiomyocytes appears to play a permissive role for depolarization induced by elevation of intracellular Ca2+.
|
