Generation of disease models for neurodegenerative disorders by deleting selenoprotein synthesis
| Project/Area Number |
22790268
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
SUZUKI Takafumi 東北大学, 大学院・医学系研究科, 助教 (70508308)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 含セレン蛋白質 / SeCys-tRNA / 酸化ストレス / 抗酸化酵素 / Nrf2 / 神経変性 |
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| Research Abstract |
We generated disease models for neurodegenerative disorders by deleting selenoproteins, a major member of antioxidant enzymes. We have found that transcriptional factor Nrf2 activate in the selenoprotein-deficient neuronal tissue. In the absence of Nrf2, selenoprotein deficiency in neuronal tissue cause severe degenerative phenotype. These results reveal that selenoproteins are essential for maintaining homeostasis of neuronal tissue, and that Nrf2 has cytoprotective role against loss of selenorpoteins.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung2010
Author(s)
Satoh H, Moriguchi T, Taguchi K, Takai J, Maher JM, Suzuki T, Winnard PT Jr, Raman V, Ebina M, Nukiwa T, Yamamoto M
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Journal Title
Carcinogenesis
Volume: 31
Pages: 1833-1843
Related Report
Peer Reviewed
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