| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
In this study, we demonstrated that a GATA binding element located at 77 kb upstream of Gata2 gene is an enhancer of Gata2 gene in hematopoietic progenitors using bacterial artificial chromosome(BAC)transgenic mice. The-77 enhancer is close to protooncogene EVI1 in translocated/inverted alleles between 3q21 and 3q26 in 3q21q26 syndrome. Therefore, we generated transgenic mice harboring a BAC transgene recapitulating the 3q21q26 inversion allele in order to examine contribution of the-77 enhancer to the EVI1 gene overexpression in 3q21q26 syndrome.
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