Identification of the mechanisms of pulmonary surfactant phospholipid transport and lamellar body production.
| Project/Area Number |
22790270
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HISHIKAWA Daisuke 東京大学, 大学院・医学系研究科, 特任研究員 (10569966)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 生体分子医学 / 肺サーファクタント / リン脂質移送 / 肺胞2型上皮細胞 / リン脂質輸送 |
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| Research Abstract |
In this study, I identified the candidate gene "A" for pulmonary surfactant phospholipid transporter. Gene "A" was highly expressed in mouse lung, especially in alveolar type II(ATII) cells, which produce the pulmonary surfactant. Furthermore, the expression of gene "A" was promoted during perinatal periods in mouse lung. The candidate "A" was localized at lamellar bodies in mouse primary ATII cells. The recombinant protein "A" was GTP-dependently bound to the disaturated phosphatidylcholine, which is the major component of pulmonary surfactant phospholipid.
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Report
(3 results)
Research Products
(1 results)
