| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Research Abstract |
Autophagy is a major intracellular degradation system. In this study, we analyzed the role of autophagy in nutrient metabolism by using autophagy-deficient mice. In Atg5-deleted liver, gluconeogenesis and beta-oxidation were not induced by starvation. Amino acid concentration and protein synthesis rate were reduced in the knockout liver. These results suggest that autophagy is important for amino acid supply and protein synthesis during starvation in the liver.
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