The contribution of Delta signaling regulated by γ-secretase on the differentiation of peripheral CD4 T cells
| Project/Area Number |
22790278
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Notch / Delta / シグナル伝達 / γ-セクレターゼ / Th細胞 |
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| Research Abstract |
I examined the contribution of Notch or Delta signaling to Th differentiation under various culture conditions. Although there was no effect of Notch/Delta signaling on Th1, Th2 and Treg differetiation, a slight effect of Notch signalingon Th17 differentiation under neutral condition was observed. Since this effect was notdetected in the Th17 culture condition, this result suggests that Th17 differentiation by Notch signaling was something different from that in the usual Th17 culture condition.
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Report
(4 results)
Research Products
(12 results)
