The contribution of Delta signaling regulated by γ-secretase on the differentiation of peripheral CD4 T cells

• Project/Area Number: 22790278
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Shinshu University
• Principal Investigator: NAGASE Hisashi 信州大学, 医学部, 助教 (70303451)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: Notch / Delta / シグナル伝達 / γ-セクレターゼ / Th細胞

Research Abstract

I examined the contribution of Notch or Delta signaling to Th differentiation under various culture conditions. Although there was no effect of Notch/Delta signaling on Th1, Th2 and Treg differetiation, a slight effect of Notch signalingon Th17 differentiation under neutral condition was observed. Since this effect was notdetected in the Th17 culture condition, this result suggests that Th17 differentiation by Notch signaling was something different from that in the usual Th17 culture condition.

Research Products

• [Journal Article] Notch, APP, and Alzheimer's Disease (2012)
  • Author(s): Nakayama K, Nagase H, Koh CS, Ohkawara T. γ-Secretase-Regulated Signaling
  • Journal Title: Current Psychopharmacology. Volume: 1(2) Issue: 2 Pages: 155-166
  • DOI: 10.2174/2211556011201020155
  • Peer Reviewed
• [Journal Article] γ-Secretase-Regulated Signaling Pathways, such as Notch Signaling, Mediate the Differentiation of Hematopoietic Stem Cells, Development of the Immune System, and Peripheral Immune Responses (2011)
  • Author(s): Nagase H, Koh CS, Nakayama K
  • Journal Title: Curr Stem Cell Res Ther Volume: 6(2) Issue: 2 Pages: 131-141
  • DOI: 10.2174/157488811795495459
  • Peer Reviewed
• [Journal Article] The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis. (2011)
  • Author(s): Ohkawara T, Nagase H, Koh CS, Nakayama K.
  • Journal Title: Gene Volume: 475(1) Issue: 1 Pages: 1-9
  • DOI: 10.1016/j.gene.2010.11.014
  • Peer Reviewed
• [Journal Article] γ-Secretase-Regulated Mechanisms Similar to Notch Signaling May Play a Role in Signaling Events, Including APP Signaling, Which Leads to Alzheimer's Disease (2011)
  • Author(s): Nakayama K, Nagase H, Koh CS, Ohkawara T.
  • Journal Title: Cell Mol Neurobiol Volume: 31(6) Issue: 6 Pages: 887-900
  • DOI: 10.1007/s10571-011-9688-z
  • NAID: 120007110577
  • Peer Reviewed
• [Journal Article] γ-Secretase-Regulated Signaling Pathways, such as Notch Signaling, Mediate the Differentiation of Hematopoietic Stem Cells, Development of the Immune System, and Peripheral Immune Responses (2011)
  • Author(s): Nagase H, Koh CS, Nakayama K
  • Journal Title: Current Stem Cell Research & Therapy Volume: Vol.6 Pages: 131-141
  • Peer Reviewed
• [Journal Article] The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis (2011)
  • Author(s): Ohkawara T, Nagase H, Koh CS, Nakayama K
  • Journal Title: Gene Volume: 475 Pages: 1-9
  • Peer Reviewed
• [Book] Ohkawara T. γ-Secretase-Regulated Signaling and Alzheimer's Disease. Understanding Alzheimer's Disease (2013)
  • Author(s): Nakayama K, Nagase H, Koh CS
  • Publisher: Croatia: InTech Publishers, Inc
• [Book] Understanding Alzheimer's Disease (2013)
  • Author(s): Kohzo Nakayama, Hisashi Nagase, Chang-Sung Koh and Takeshi Ohkawara
  • Publisher: InTech Publishers, Inc.
• [Book] Amyloid precursor protein: its signaling aspect and Alzheimer's disease. Amyloids, Halcheck IP (2012)
  • Author(s): Nakayama K, Nagase H, Koh CS, Ohkawara T
  • Publisher: Vernon NR, editors. NY: Nova Science Publishers, Inc
• [Book] γ-Secretase-regulated signaling mechanisms: Notch and amyloid precursor protein. Neural Stem Cells & Therapy (2012)
  • Author(s): Nakayama K, Nagase H, Koh CS, Ohkawara T.
  • Publisher: Sun T, editor. Croatia: InTech Publishers, Inc
• [Book] Amyloids: Composition, Functions and Pathology (2012)
  • Author(s): Kohzo Nakayama, Hisashi Nagase, Chang-Sung Koh and Takeshi Ohkawara
  • Publisher: NOVA Science Publishers, Inc.
• [Book] Neural Stem Cells and Therapy (2011)
  • Author(s): Nakayama K, Nagase H, Koh CS, Ohkawara T
  • Total Pages: 28
  • Publisher: InTech Publishers, Inc.