Pathological features induced by constitutive active mutant of ERK2 : Study focused on premature cellular senescence
| Project/Area Number |
22790281
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Mie University |
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Principal Investigator |
SUGIMURA Kazuto 三重大学, 大学院・医学系研究科, 助教 (90452226)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | Erk2 / NCFC症候群 / p53 / 血球・血管内皮 / 細胞老化 / Noonan症候群 |
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| Research Abstract |
Hematopoietic and endothelial cell lineage-specific gain of function mutation of Erk2 in mice resulted in lower rate of birth, lower body weight, and lower body length. The mice had NCFC syndrome-like physical characteristics such as unique facial abnormalities, indicating that constitutive activation of Erk2 was the cause for the part of pathological features in NCFC syndrome. Moreover, p53 was likely to be involved in the phenotype, suggesting that p53-targeted treatment might be effective to the NCFC syndrome-linked pathologies.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] The Histone Chaperone Facilitates Chromatin Transcription(FACT) Protein Maintains Normal Replication Fork Rates2011
Author(s)
Takuya Abe, Kazuto Sugimura, Yoshifumi Hosono, Yasunari Takami, Motomu Akita, Akari Yoshimura, Shunsuke Tada, Tatsuo Nakayama, Hiromu Murofushi, Katsuzumi Okumura, Shunichi Takeda, Masami Horikoshi, Masayuki Seki, and Takemi Enomoto
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Journal Title
The Journal of Biological Chemistry
Volume: 286
Pages: 30504-30512
Related Report
Peer Reviewed
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[Journal Article] The histone chaperone FACT maintains replication fork rates2011
Author(s)
T.Abe, K.Sugimura, Y.Hosono, Y.Takami, M.Akita, A.Yoshimura, S.Tada, T.Nakayama, H.Murofushi, K.Okumura, S.Takeda, M.Horikoshi, M.Seki & T.Enomoto
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Journal Title
J.Biol.Chem.
Volume: 286
Issue: 35
Pages: 30504-30512
DOI
Related Report
Peer Reviewed
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[Presentation] ヒトMcm10の機能ドメインの解析2010
Author(s)
泉雅子, 柳憲一郎, 水野武, 杉村和人, 今本尚子, 奥村克純, 花岡文雄
Organizer
第33回日本分子生物学会年会第83回日本生化学会大会合同大会
Place of Presentation
神戸国際展示場
Year and Date
2010-12-07
Related Report
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