The role of cell proliferation in cellular reprogramming
Project/Area Number |
22790283
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
General medical chemistry
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | iPS細胞 / リプログラミング / 癌 |
Research Abstract |
Transcription factor-induced reprogramming requires relative longer time compared to those by nuclear transfer and cell fusion. Since cells actively proliferate during this period, we can imagine its importance in reprogramming process. However, the role of cell proliferation was unclear. In this study, we demonstrated that cell proliferation is dispensable for the initiation of reprogramming but essential for the maturation.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery2012
Author(s)
Tanaka T., Takahashi K., Yamane M., Tomida S., Nakamura S., Oshima K., Niwa A., Nishikomori R., Kambe N., Hara H., Mitsuyama M., Morone N., Heuse J.E., Yamamoto T., Watanabe A., Sato-Otsubo A., Ozawa S., Asaka I., Heike T., Yamanaka S., Nak
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Journal Title
Blood
Volume: 120(6)
Issue: 6
Pages: 1299-308
DOI
Related Report
Peer Reviewed
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[Journal Article] Dental pulp cells for induced pluripotent stem cell banking2010
Author(s)
Tamaoki N, Takahashi K, Tanaka T, Ichisaka T, Aoki H, Takeda-Kawaguchi T, Iida K, Kunisada T, Shibata T, Yamanaka S, Tezuka K
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Journal Title
J Dent Res
Volume: 89(8)
Issue: 8
Pages: 773-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Dental Pulp Cells for Induced Pluripotent Stem Cell Banking.2010
Author(s)
Tamaoki, N., Takahashi, K., Tanaka, T., Ichisaka, T., Aoki, H., Takeda-Kawaguchi, T., Iida, K., Kunisada, T., Shibata, T., Yamanaka, S., Tezuka, K.
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Journal Title
J Dent Res
Volume: 89
Pages: 773-778
Related Report
Peer Reviewed
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