Analyses of intercellular signaling during generation of induced pluripotent stem cell from somatic cells

Research Project

Project/Area Number	22790286
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	General medical chemistry
Research Institution	Kyoto University
Principal Investigator	AOI Takashi 京都大学, iPS細胞研究所, 教授 (00546997)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	人工多能性幹細胞 / 細胞間シグナリング / NF-_kB / NF-kB / NF-κB
Research Abstract	Microarray analysis showed the expression level of many genes involved in intercellular signaling changed during generation of induced pluripotent stem(iPS) cells from somatic cells. The genes included diverse downstream targets of NF-kB signal. To address the function of NF-kB signaling during iPS cell generation process, we conducted loss-of-function experiment and demonstrated that NF-kB signaling have positive effect on the reprogramming process, but not maintenance of established iPS cells.

Report

(3 results)