CNS regeneration by regulating axonal transport

• Project/Area Number: 22790289
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Kansai University of Health Sciences
• Principal Investigator: HATA Katsuhiko 関西医療大学, 保健医療学部, 研究員 (60506228)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 再生医学 / 中枢神経 / 軸索 / 脊髄 / 軸索輸送 / dynactin

Research Abstract

We observed the phenomenon of axotomy-induced axonogenesis in rat embryonic hippocampal neurons in vitro and showed the involvement of retrograde transport by dynein-dynactin complex in this phenomenon. Moreover, Importin ss was locally translated after axotomy followed by the interaction with the dynein-importin α complex. These findings suggest that local translation and retrograde transport system in injured axons play an important roles in the axotomy-induced axonogenesis of embryonic hippocampal neurons.

Research Products

• [Journal Article] Axotomy induces axonogenesis in hippocampal neurons through STAT3 (2011)
  • Author(s): Ohara, R., Fujita, Y., Hata, K., Nakagawa, M. and Yamashita, T.
  • Journal Title: Cell Death Dis Volume: 2
• [Journal Article] Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on Importin ss (2011)
  • Author(s): Ohara, R., Hata, K., Yasuhara, N., Mehmood, R., Yoneda, Y., Nakagawa, M. and Yamashita, T.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 405 Pages: 697-702
• [Journal Article] Axotomy induces axonogenesis in hippocampal neurons through STAT3. (2011)
  • Author(s): Ohara, R., Fujita, Y., Hata, K., Nakagawa, M. and Yamashita, T.
  • Journal Title: Cell Death Dis. Volume: 2 Issue: 6 Pages: e175-e175
  • DOI: 10.1038/cddis.2011.59
  • Peer Reviewed
• [Journal Article] Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on importinβ (2011)
  • Author(s): Ohara, R., Hata, K., Yasuhara, N., Mehmood, R., Yoneda, Y., Nakagawa, M. and Yamashita, T
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 405 Issue: 4 Pages: 697-702
  • DOI: 10.1016/j.bbrc.2011.01.108
  • Peer Reviewed
• [Journal Article] Neogenin : A receptor for bone morphogenetic proteins. (2011)
  • Author(s): Hagihara, M., Endo, M., Hata, K., Higuchi, C., Takaoka, K., Yoshikawa, H., Yamashita, T.
  • Journal Title: The Journal of Biological Chemistry Volume: 286 Pages: 5157-5165
  • Peer Reviewed