Analysis of the role of deubiquitinating enzyme A20 using mouse model
| Project/Area Number |
22790292
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
INAGAKI Maiko 広島大学, 原爆放射線医科学研究所, 助教 (70543396)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 炎症 / がん / 癌 / シグナル伝達 / 細胞内シグナル伝達 |
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| Research Abstract |
In this study, we generated tissue-specific A20 knockout mice. Intestine epithelium-specific A20 knockout mice did not show obvious phenotype. Skin-specific A20 knockout mice showed growth retardation after weaning. We have performed historogical analysis, but we couldn't find any defect in A20 deficient skin. Instead, we found inflammation and hyperplasia on the non-glandular portions of the stomach. These data suggests A20 gene deletion in the non-glandular portions of the stomach of skin-specific A20 knockout mice, because of ectopic expression of cre. As a result, these mice might have stomach inflammation and growth reterdation.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Morioka S, Inagaki M, Komatsu Y, Mishina Y, Matsumoto K, Ninomiya-Tsuji J2012
Author(s)
Morioka S, Inagaki M, Komatsu Y, Mishina Y, Matsumoto K, Ninomiya-Tsuji J
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Journal Title
Blood
Volume: 120(18)
Issue: 18
Pages: 3846-57
DOI
Related Report
Peer Reviewed
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