Research Project
Grant-in-Aid for Young Scientists (B)
In the present study, we analyzed enzymes metabolizing the anti-inflammatory lipid, N-acylethanolamine(NAE). We found that NAE-hydrolyzing acid amidase(NAAA), a lysosomal enzyme degrading NAEs, is activated by endogenous substances such as some phospholipids and dihydrolipoic acid and that several lipophilic amines are new inhibitors of NAAA. Furthermore, we suggested that HRASLS1, a member of the tumor suppressor HRASLS family, is involved in NAE biosynthesis by its N-acyltransferase activity.
All 2012 2011 2010 Other
All Journal Article (19 results) (of which Peer Reviewed: 16 results) Presentation (30 results) Remarks (3 results)
Journal of Biological Chemistry
Volume: 287 Pages: 2706-2718
ACS Chem Neurosci
Volume: (印刷中) Issue: 5 Pages: 379-385
10.1021/cn300007s
Bioorganic & Medicinal Chemistry
Volume: 20 Pages: 3658-3665
Bioorg Med Chem
Volume: 20(11) Issue: 11 Pages: 3658-3665
10.1016/j.bmc.2012.03.065
BioFactors
Volume: 37 Pages: 1-7
Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids
Volume: 1811 Pages: 508-512
Volume: 1811 Pages: 565-577
Journal of Lipid Research
Volume: 52 Pages: 1927-1935
生化学
Volume: 83 Pages: 485-494
10029068825
日本薬理学雑誌
Volume: 138 Pages: 8-12
ビタミン
Volume: 85 Pages: 604-607
110008762054
Biochim Biophys Acta-Mol Cell Biol Lipids
Volume: 1811 Issue: 9 Pages: 508-512
10.1016/j.bbalip.2011.06.020
Volume: 1811 Issue: 10 Pages: 565-577
10.1016/j.bbalip.2011.07.009
110009612886
Volume: 52 Issue: 11 Pages: 1927-1935
10.1194/jlr.m015081
Progress in Lipid Research
Volume: 49 Pages: 299-315
Volume: 1801 Pages: 1274-1285
Biochimica et Biophysica Acta
http://www.kms.ac.jp/~biochem/index.html