Identificat i on of physiological roIes of a new Iipidmediator, 12-HHT
Project/Area Number |
22790296
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
General medical chemistry
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Research Institution | Kyushu University |
Principal Investigator |
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 生理活性脂質 / 受容体 / BLT2 / 12-HHT / ロイコトリエン / シクロオキシゲナーゼ / トロンボキサン / 脂質 / GPCR / LTB4 / 大腸炎 / DSS / 炎症 |
Research Abstract |
12-HHT is a new lipid mediator which was identified as a natural ligand for BLT2. BLT2-deficient mice exhibited severe intestinal inflammation in mice colitis model. MDCK cells transfected with BLT2 exhibited enhanced barrier function as measured by transepithelial electrical resistance(TER) and FITC-dextran leakage. Thus, BLT2 appears to protect against colitis, possibly by enhancing barrier function in epithelial cells of the colon.
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Report
(3 results)
Research Products
(50 results)
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[Journal Article] Protective role of leukotriene B4 receptor BLT2 in murine model of inflammatory colitis2010
Author(s)
Iizuka Y, Okuno T, Saeki K, Uozaki H, Okada S, Misaka T, Sate T, Ton H, Fukayama M, Takeda N, Kita Y, Shimizu T, Nakamura M, and Yokomizo T.
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Journal Title
Faseb J
Volume: 24
Pages: 4678-4690
Related Report
Peer Reviewed
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