| Project/Area Number |
22790301
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | PIポリアミド / 固相合成法 / ユニーク型PIポリアミド / ポリアミドブロック / ABCA1 / 遺伝子発現抑制 / 水溶性の向上 / 環状PIポリアミド / リシンテール / PEG-HMPB-レジン / ブロックユニット |
|---|
| Research Abstract |
Cross form PI polyamide having 0alaninelPy or p-alanine/lm was succeeded in making into a target all DNA sequence without GGGG and CCCC. Then, for the synthesis of long chain PI polyamide recognizing 12 base-pair DNA sequence, 2-3 mer PI polyamide blocks by solid phase synthesis using HMPB resin was developed and the long chain PI polyamide could be synthesized elongating these PI polyamide blocks. And it was established that solid phase synthesis of the cyclic PI polyamides more strong DNA binding than hair-pin PI polyamide.
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