Analysis of Nrf2 function in cytokine network regulation

• Project/Area Number: 22790304
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: Hirosaki University
• Principal Investigator: MIMURA Junsei 弘前大学, 大学院・医学研究科, 講師 (60344884)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 分子病態学 / 酸化ストレス / 免疫応答 / 神経栄養因子 / グリア細胞

Research Abstract

In this study, our data revealed that the oxidative stress-inducible transcription factor Nrf2 mediates carnosiid-inducible NGF gene expression directly in glial cells. We also found that carnosic acidacacnd IL-1β cooperatively enhances NGFgene expression. Since NGF functions as a neurotrophic factor and inflammatory cytokine, these results indicate that Nrf2 may regulate neural or immune cell function through NGF gene regulation.

Research Products

• [Journal Article] Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes (2011)
  • Author(s): Mimura J, Kosaka K, Maruyama A, Satoh T, Harada N, Yoshida H, Satoh K, Yamamoto M, Itoh K
  • Journal Title: J Biochem Volume: 150 Issue: 2 Pages: 209-217
  • DOI: 10.1093/jb/mvr065
  • NAID: 10030587033
  • Peer Reviewed
• [Journal Article] Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation (2011)
  • Author(s): Yoshida H, Mimura J, Imaizumi T, Matsumiya T, Ishikawa A, Metoki N, Tanji K, Ota K, Hayakari R, Kosaka K, Itoh K, Satoh K
  • Journal Title: Neuroscience Research Volume: 69 Pages: 291-298
  • Peer Reviewed
• [Presentation] NGF induction by the oxidative stress responsive transcription factor Nrf2 (2011)
  • Author(s): 三村純正
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 神奈川県
• [Presentation] NGF induction by the oxidative stress responsive transcription factor Nrf2 (2011)
  • Author(s): 三村純正
  • Organizer: 第34回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] NGF induction by the oxidative stress responsive transcription factor Nrf2 (2010)
  • Author(s): Junsei Mimura
  • Organizer: The 12th meeting of Hirosaki International Forum of Medical Science
  • Place of Presentation: 青森県
  • Year and Date: 2010-10-29
• [Presentation] NGF induction by the oxidative stress responsive transcription factor Nrf2 (2010)
  • Author(s): 三村純正
  • Organizer: The 12th meeting of Hirosaki International Forum of Medical Science
  • Place of Presentation: 弘前大学医学部コミュニケーションセンター(青森県)
  • Year and Date: 2010-10-29
• [Presentation] 酸化ストレス応答性転写因子Nrf2によるNGF発現制御 (2010)
  • Author(s): 三村純正
  • Organizer: 第63回日本酸化ストレス学会
  • Place of Presentation: 神奈川県
  • Year and Date: 2010-06-24
• [Presentation] 酸化ストレス応答性転写因子Nrf2によるNGF発現制御 (2010)
  • Author(s): 三村純正
  • Organizer: 第63回日本酸化ストレス学会
  • Place of Presentation: 神奈川県民ホール(神奈川県)
  • Year and Date: 2010-06-24
• [Remarks]
  • URL: http://www.med.hirosaki-u.ac.jp/~admed/department/index.html