Analysis of protein kinases involved in the maintenance of stemness of glioblastoma stem cells
| Project/Area Number |
22790305
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Yamagata University |
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Principal Investigator |
SUNAYAMA Jun 山形大学, 医学部, 助教 (80466606)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | glioma / stemness / glioblasotma / PI3 kinase / mTOR / glioblastoma |
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| Research Abstract |
In this study, we searched for protein kinases involved in the maintenance of glioblastoma stem cells and demonstrated critical roles for PI3K/mTOR and MAPK in glioblastoma stem cell maintenance. Significantly, PI3K/mTOR and MAPK acted on a common molecule, i.e., the FOXO3 transcription factor, whose activity was restrained through phosphorylation by these kinases in glioblastoma stem cells. Our results suggest that FOXO3 as well as these kinases could be rational molecular targets for stem cell-targeted glioblastoma therapies.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] FoxO 3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity2011
Author(s)
Sunayama J, Sato A, Matsuda KI, Tachibana K, Watanabe E, Seino S, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C
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Journal Title
Stem Cells
Volume: 29
Pages: 1327-1337
Related Report
Peer Reviewed
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[Journal Article] Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells2010
Author(s)
Sunayama J, Matsuda KI, Sato A, Tachibana K, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C
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Journal Title
Stem Cells
Volume: 28
Pages: 1930-1939
Related Report
Peer Reviewed
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[Journal Article] Dual blocking of mTor and PI3K elicits a pro-differentiation effect on glioblastoma stem like-cells2010
Author(s)
Sunayama J, Sato A, Matsuda KI, Tachibana K, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C
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Journal Title
Neuro-Oncol
Volume: 12
Pages: 1205-1219
Related Report
Peer Reviewed
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[Presentation] グリオーマ幹細胞におけるFoxO3aを介した分化と造腫瘍能の制御2011
Author(s)
佐藤篤, 砂山潤, 松田憲一朗, 立花研, 渡部江梨子, 清野静香, 鈴木香, 成田善孝, 渋井壮一郎, 富山新太, 北中千史, 嘉山孝正
Organizer
第29回日本脳腫瘍学会学術総会
Place of Presentation
下呂(水明館)
Year and Date
2011-11-27
Related Report
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