| Project/Area Number |
22790305
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Yamagata University |
|---|
Principal Investigator |
SUNAYAMA Jun 山形大学, 医学部, 助教 (80466606)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | glioma / stemness / glioblasotma / PI3 kinase / mTOR / glioblastoma |
|---|
| Research Abstract |
In this study, we searched for protein kinases involved in the maintenance of glioblastoma stem cells and demonstrated critical roles for PI3K/mTOR and MAPK in glioblastoma stem cell maintenance. Significantly, PI3K/mTOR and MAPK acted on a common molecule, i.e., the FOXO3 transcription factor, whose activity was restrained through phosphorylation by these kinases in glioblastoma stem cells. Our results suggest that FOXO3 as well as these kinases could be rational molecular targets for stem cell-targeted glioblastoma therapies.
|
