Analysis of the regulatory mechanisms of Y-family DNA polymerases and its roles in precancerous lesions
| Project/Area Number |
22790306
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 発がん / ゲノム不安定性 / 複製ストレス応答 / 細胞老化 / Y-family DNAポリメラーゼ / 損傷乗り越えDNA合成 / 癌 / 複製ストレス |
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| Research Abstract |
In precancerous lesions, oncogenic signals induce cellular senescence, causing tumor suppression ; whereas they promote genomic instability, leading to tumor progression. We studied the role of DNA replicative stress in cyclin E over expressed U2OS human cells. Our data suggest that Y family Polymerases play a role in oncogene-induced DNA re-replication.
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Report
(3 results)
Research Products
(17 results)
