The progressive nephropathy in Skp2-p27 double knockout mice.

• Project/Area Number: 22790310
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: SUZUKI Sayuri 浜松医科大学, 医学部, 特任研究員 (80568949)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 細胞増殖 / タンパク分解 / 腎障害 / p27 / Skp2 / Cks1

Research Abstract

p27, is known a Skp2 target, most increased in the UUO kidney in Skp2^<-/-> mice. The ameliorated UUO renal injure by Skp2-deficiency was canceled by the additional p27-deficiency in Skp2^<-/-> p27^<-/-> mice. These findings suggest a pathogenic role of the reduction in p27 targeted by Skp2 in the progression of nephropathy in UUO mice.

Research Products

• [Journal Article] The amelioration of renal damage in Skp2-deficient mice is canceled by p27^<Kip1> deficiency in Skp2^<-/-> p27^<-/-> mice (2012)
  • Author(s): Suzuki, S., Fukasawa, H., Misaki, T., Togawa A., Ohashi, N., et al.
  • Journal Title: PLoS ONE Volume: 7(4) Pages: 1-9
  • Peer Reviewed
• [Journal Article] The amelioration of renal damage in Skp2-deficient mice is canceled by p27^<Kip1> deficiency in Skp2^<-/-> p27^<-/-> mice (2012)
  • Author(s): 鈴木小由里
  • Journal Title: PLoS ONE Volume: 7
  • Peer Reviewed
• [Journal Article] Up-regulation of Cks1 and Skp2 with TNFα/NF-κB Signaling in Chronic Progressive Nephropathy (2011)
  • Author(s): Suzuki S., Fukasawa H., Misaki T., Togawa A., Ohashi N., Kitagawa K., Kotake Y., Niida H., Hishida A., Yamamoto T., and Kitagawa M.
  • Journal Title: Genes Cells Volume: 16 Pages: 1110-1120
  • Peer Reviewed
• [Journal Article] Up-regulation of Cksl and Skp2 with TNFcx/NFkB signaling in chronic progressive nephropathy. (2011)
  • Author(s): Suzuki, S., et al.
  • Journal Title: Genes Cells Volume: 16 Issue: 11 Pages: 1110-1120
  • DOI: 10.1111/j.1365-2443.2011.01553.x
  • Peer Reviewed
• [Journal Article] Hepatocyte Growth Factor stimulated cell scattering requires ERK and Cdc42-dependent Tight Junction Disassembly (2010)
  • Author(s): Togawa A., Sfakianos J., Ishibe S., Suzuki S., Fujigaki Y., Kitagawa M., Mellman I., Cantley L. G.
  • Journal Title: Biochem Biophys Res Commun Volume: 400 Pages: 271-277
  • Peer Reviewed
• [Journal Article] Reduction of transforming growth factor-b type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma (2010)
  • Author(s): Fukasawa H, Yamamoto T, Fujigaki Y, Misaki T, Ohashi N, Takayama T, Suzuki S, Mugiya S, Oda T, Uchida C, Kitagawa K, Hattori T, Hayashi H, Ozono S, Kitagawa M and Hishida A
  • Journal Title: Int. J. Cancer Volume: 127 Pages: 1517-1525
  • Peer Reviewed
• [Presentation] 慢性進行性腎障害におけるTNFa/NF-kBシグナル伝達によるCks1およびSkp2の発現亢進 (2011)
  • Author(s): 鈴木小由里、深澤洋敬、三崎太郎、北川恭子、神武洋二郎、丹伊田浩行、山本龍夫、北川雅敏
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-12-14
• [Presentation] 慢性進行性腎障害におけるTNFa/NF-kBシグナル伝達によるCks1およびSkp2の発現亢進 (2011)
  • Author(s): 鈴木小由里
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-12-14
• [Presentation] 慢性進行性腎障害におけるNF-・B経路によるSkp2およびCks1の発現亢進 (2011)
  • Author(s): 鈴木小由里、深澤洋敬、三崎太郎、戸川証、北川恭子、神武洋二郎、丹伊田浩行、山本龍夫、北川雅敏
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-09-22
• [Presentation] 慢性進行性腎障害におけるNF-・B経路によるSkp2およびCks1の発現亢進 (2011)
  • Author(s): 鈴木小由里
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-09-22
• [Presentation] 慢性進行性腎障害におけるCks1およびSkp2の発現亢進の意義 (2010)
  • Author(s): 鈴木小由里
  • Organizer: BMB2010
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Remarks]
  • URL: http://www.hama-med.ac.jp/uni_education_igakubu_igaku_seika1.html