Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Research Abstract |
p27, is known a Skp2 target, most increased in the UUO kidney in Skp2^<-/-> mice. The ameliorated UUO renal injure by Skp2-deficiency was canceled by the additional p27-deficiency in Skp2^<-/-> p27^<-/-> mice. These findings suggest a pathogenic role of the reduction in p27 targeted by Skp2 in the progression of nephropathy in UUO mice.
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