| Project/Area Number |
22790315
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
YAMAGATA Kaoru 神戸大学, 大学院・医学研究科, グローバルCOE研究員 (80533786)
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|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Wnt5a / Ror2 / Dvl2 / AP1 / MMP-13 / 軟骨内骨化 / 骨肉腫 / 遺伝子発現 |
|---|
| Research Abstract |
Constitutively active Wnt5a-Ror2 signaling results in activated Dishevelled2, Rac1, JNK and transcriptional factor AP1 in human osteosarcoma SaOS-2 cells, resulting in subsequent induced expression of MMP-13 that is capable of degrading extracellular matrix, involved in cancer cell invasiveness. Wnt5a-Ror2 signaling involves endochondral ossification of cartilaginous tissue in mouse embryo, indicating crucial role in developmental conditions.
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