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Molecular mechanism of cancer cells invasiveness regulated by Ror2 signaling in human osteosarcoma cells

Research Project

Project/Area Number 22790315
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionKobe University

Principal Investigator

YAMAGATA Kaoru  神戸大学, 大学院・医学研究科, グローバルCOE研究員 (80533786)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsWnt5a / Ror2 / Dvl2 / AP1 / MMP-13 / 軟骨内骨化 / 骨肉腫 / 遺伝子発現
Research Abstract

Constitutively active Wnt5a-Ror2 signaling results in activated Dishevelled2, Rac1, JNK and transcriptional factor AP1 in human osteosarcoma SaOS-2 cells, resulting in subsequent induced expression of MMP-13 that is capable of degrading extracellular matrix, involved in cancer cell invasiveness. Wnt5a-Ror2 signaling involves endochondral ossification of cartilaginous tissue in mouse embryo, indicating crucial role in developmental conditions.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2012 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase(MMP)-13 expression2012

    • Author(s)
      K. Yamagata, X. Li, S. Ikegaki, C. Oneyama, M. Okada, M. Nishita, Y. Minami.
    • Journal Title

      J. Biol. Chem

      Volume: 287(2) Pages: 1588-99

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase(MMP-13) expression2012

    • Author(s)
      Yamagata K, Li X, Ikegaki S, Oneyama C, Okada M, Nishita M, Minami Y
    • Journal Title

      J Biol Chem

      Volume: 287(2) Issue: 2 Pages: 1588-99

    • DOI

      10.1074/jbc.m111.315127

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell/tissue-tropic functions of Wnt5a signaling in normal and cancer cells2010

    • Author(s)
      西田満、榎本真宏、山形薫、南康博
    • Journal Title

      Trends in Cell Biology

      Volume: 20 Pages: 346-54

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase(MMP)-13 expression2011

    • Author(s)
      山形薫、池垣俊吉、李欣、南康博
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression2011

    • Author(s)
      山形薫、池垣俊吉、李欣、南康博
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜会場
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase(MMP)-13 expression2011

    • Author(s)
      山形薫、池垣俊吉、李欣、南康博
    • Organizer
      Joint Symposium on Integrative Membrane Biology and Signal Transduction Medicine
    • Place of Presentation
      University of Washington-Kobe University神戸
    • Year and Date
      2011-12-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Molecular analysis of MMP13 gene expression by Wnt5a-Ror2 signaling in human osteosarcoma cells2011

    • Author(s)
      山形薫、池垣俊吉、李欣、南康博
    • Organizer
      第3回次世代シグナル伝達医学グローバルCOE研究討論会
    • Place of Presentation
      淡路
    • Year and Date
      2011-07-11
    • Related Report
      2011 Final Research Report
  • [Presentation] がんの進展におけるWnt5a-Rorシグナルの機能解析2011

    • Author(s)
      山形薫、南康博
    • Organizer
      第3回シグナルネットワーク研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysis of MMP13 gene expression induced by Wnt5a-Ror2 signaling in human osteosarcoma cell line2010

    • Author(s)
      山形薫、李欣、渡邊康秀、南康博
    • Organizer
      第2回次世代シグナル伝達医学グローバルCOE研究討論会
    • Place of Presentation
      淡路
    • Year and Date
      2010-07-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Wnt5a-Ror2シグナルによる細胞極性・移動制御とがんの浸潤2010

    • Author(s)
      南康博、山形薫、西田満
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2010-05-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Wnt5a-Ror2シグナルによる細胞極性・移動制御とがんの浸潤2010

    • Author(s)
      南康博、山形薫、西田満
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪国際会議場(大阪府)(招待講演)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.kobe-u.ac.jp/medzoo/

    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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