Roles of leukotriene receptor signaling in cell proliferation
Project/Area Number |
22790320
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Pathological medical chemistry
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Research Institution | Kyushu University |
Principal Investigator |
SAEKI Kazuko 九州大学, 大学院・医学研究院, 助教 (00553273)
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Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 生理活性脂質 / GPCR / 病態モデル |
Research Abstract |
BLT2 is a receptor for LTB_4 and 12-HHT and expressed on the epithelium of skin and intestine. To clarify the role of BLT2 in these tissues, the models of inflammatory colitis, tumorigenesis in the colon, and skin wound healing were performed. It was revealed that BLT2 suppresses inflammatory colitis and tumorigenesis in the colon and promotes skin wound healing.
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Report
(3 results)
Research Products
(48 results)
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[Journal Article] Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis2010
Author(s)
Iizuka, Y., Okuno, T., Saeki, K., Uozaki, H., Okada, S., Misaka, T., Sato, T., Toh, H., Fukayama, M.,Takeda, N., Kita, Y., Shimizu, T., Nakamura, M., and Yokomizo, T.
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Journal Title
FASEB J
Volume: 24
Issue: 12
Pages: 4678-4690
DOI
Related Report
Peer Reviewed
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[Journal Article] Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis.2010
Author(s)
Iizuka Y, Okuno T, Saeki K, Uozaki H, Okada S, Misaka T, Sato T, Toh H, Fukayama M, Takeda N, Kita Y, Shimizu T, Nakamura M, Yokomizo T
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Journal Title
FASEB J
Volume: 24(12)
Pages: 4678-4690
Related Report
Peer Reviewed
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