| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Myostatin is a potent negative regulator of skeletal muscle growth. In this study, we found that the muscle in myostatin knockout mice changed any metabolic associated factors. In addition we crossed myostatin knockout mice with mdx mice, a model for Duchenne muscular dystrophy. The muscle in crossed mice was showed hypertrophy and hyperplasia, but the ratio of regenerating muscle fiber was nearly identical to mdx mice. Improvement of muscular dystrophy was considered hypertrophy and hyperplasia of increased muscle.
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