Phosphorylation-mediated regulation of Nrf1 in the pathogenesis of steatohepatitis
| Project/Area Number |
22790329
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Doshisha University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 代謝異常学 / 細胞・組織 / シグナル伝達 / 脂質 |
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| Research Abstract |
I identified β-TrCP and CK2 as Nrf1-binding proteins. I found that β-TrCP regulates Nrf1 degradation in the nucleus and its transcriptional activity(Tsuchiya et al.(2011) Mol. Cell. Biol. 31 : 4500-4512). I also found that CK2 phosphorylates Nrf1 and suppresses its transcriptional activity, thereby impairs Nrf1-dependent induction of proteasome gene expression. These results suggest that phosphorylation of Nrf1 is a novel therapeutic target for ameliorating accumulation of protein aggregates observed in steatohepatitis and neurodegenerative diseases.
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Report
(3 results)
Research Products
(5 results)
