Regulation of APP metabolism by glycosyltransferase
Project/Area Number |
22790330
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Pathological medical chemistry
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Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
Principal Investigator |
MANYA Keiko 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (70415496)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | アルツハイマー病 / 糖転移酵素 / APP / bisecting GlcNAc |
Research Abstract |
It was revealed that glycosyltransferase GnT-III affects APP metabolism and glycan modification by GnT-III decreases Aβproduction in the previous study. The aim of this study is to find natural compound that decreases Aβproduction by increase of GnT-III expression. As a result, a type of Polyphenol promoted GnT-III expression.
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Report
(3 results)
Research Products
(8 results)
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[Presentation] Structural alteration of N-glycan on APP andβ-amyloid production2010
Author(s)
Akasaka-Manya, K., Manya, H., Sakurai, Y., Saito, Y., Murayama, S., Endo, T
Organizer
7th International Symposium on Glycosyltransferase
Place of Presentation
Tokyo
Related Report
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[Presentation] Protective effect of N-glycan bisecting GlcNAc residues onβ-amyloid produc tion in Alzheimer's disease2010
Author(s)
Akasaka-Manya, K., Manya, H., Sakurai, Y., Wojczyk, B. S., Kozutsumi, Y., Saito, Y., Taniguchi, N., Murayama, S., Spitalnik, S. L., and Endo, T
Organizer
The 28th Naito Conference Glycan Expression and Regulation[I]
Place of Presentation
Hayama, Japan
Related Report
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[Presentation] Protective effect of N-glycan bisecting GlcNAc residues on β-amyloid production in Alzheimer's disease.2010
Author(s)
Akasaka-Manya, K., Manya, H., Sakurai, Y., Wojczyk, B.S., Kozutsumi, Y., Saito, Y., Taniguchi, N., Murayama, S., Spitalnik, S.L., Endo, T.
Organizer
The 28th Naito Conference Glycan Expression and Regulation [I]
Place of Presentation
Hayama, Japan
Related Report
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[Presentation] Structural alteration of N-glycan on APP and β-amyloid production. GlycoT 2010 (7th International Symposium on Glycosyltransferase)2010
Author(s)
Akasaka-Manya, K., Manya, H., Sakurai, Y., Saito, Y., Murayama, S., Endo, T.
Organizer
GlycoT 2010 (7th International Symposium on Glycosyltransferase)
Place of Presentation
Tokyo, Japan
Related Report
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