Identification and expression analysis of genes controlled by a Alzheimer's disease susceptibility region including APOE
| Project/Area Number |
22790331
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human genetics
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ゲノム医科学 / アルツハイマー病 / 感受性遺伝子 / ゲノム / ゲノム医学 |
|---|
| Research Abstract |
Alzheimer's disease(AD) is the most common form of dementia in the elderly. Molecular mechanisms underlying the progression of AD neuropathological hallmarkes, senile plaques(SP) and neurofibrillary tangles(NFT), in the brain remains to be resolved. To identify genes associated with Braak SP-NFT stage criteria, we conducted a genome-wide gene expression analysis. Postmortem brain tissues from 71 brain donor subjects were used. Genomic DNAs were prepared from the frontal cortices for APOE genotyping as well as whole-genome single nucleotide polymorphisms and copy number variation genotyping. Total RNAs were isolated, and then used for expression profiling of whole-exon transcripts. Seventy-one brain donors were grouped into several groups according to Braak SP-NFT stages, and expression levels of each gene were compared in view of APOE genotypes. We found that more than 10 genes were significantly associated with Braak SP-NFT stage criteria
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Report
(3 results)
Research Products
(34 results)
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[Journal Article] Evidence for a Common Founder and Clinical Characteristics of Japanese Families with the MAPT R406W Mutation2011
Author(s)
Ikeuchi T, Imamura T, Kawase Y, Kitade Y, Tsuchiya M, Tokutake T, Kasuga K, Yajima R, Tsukie T, Miyashita A, Sugishita M, Kuwano R, Nishizawa M
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Journal Title
Dement Geriatr Cogn Disord Extra
Volume: 1
Pages: 267-275
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Peer Reviewed
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[Journal Article] Neuroblastoma amplified sequence gene is associated with a novel short stature syndrome characterised by optic nerve atrophy and Pelger-Huet anomaly2010
Author(s)
Maksimova N, Hara K, Nikolaeva I, Chun-Feng T, Usui T, Takagi M, Nishihira Y, Miyashita A, Fujiwara H, Oyama T, Nogovicina A, Sukhomyasova A, Potapova S, Kuwano R, Takahashi H, Nishizawa M, Onodera O
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Journal Title
J Med Genet
Volume: 47
Pages: 538-548
Related Report
Peer Reviewed
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[Journal Article] Sporadic four-repeat tauopathy with frontotemporal lobar degeneration, Parkinsonism, and motor neuron disease : a distinct clinicopathological and biochemical disease entity2010
Author(s)
Fu YJ, Nishihira Y, Kuroda S, Toyoshima Y, Ishihara T, Shinozaki M, Miyashita A, Piao YS, Tan CF, Tani T, Koike R, Iwanaga K, Tsujihata M, Onodera O, Kuwano R, Nishizawa M, Kakita A, Ikeuchi T, Takahashi H
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Journal Title
Acta Neuropathol
Volume: 120
Pages: 21-32
Related Report
Peer Reviewed
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[Journal Article] TRPM7 Is Not Associated With Amyotrophic Lateral Sclerosis-Parkinsonism Dementia Complex in the Kii Peninsula of Japan2010
Author(s)
Hara K, Kokubo Y, Ishiura H, Fukuda Y, Miyashita A, Kuwano R, Sasaki R, Goto J, Nishizawa M, Kuzuhara S, Tsuji S
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Journal Title
Am J Med Genet Part B
Volume: 153B
Pages: 310-313
Related Report
Peer Reviewed
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[Presentation] The Japanese Genetic Study Consortium for Alzheimer's Disease(JGSCAD,代表:井原康夫).アルツハイマー病脳組織におけるSORL1の発現解析2010
Author(s)
温雅楠,宮下哲典,月江珠緒,齊藤祐子,初田裕幸,村山繁雄,柿田明美,高橋均,北村信隆,赤澤宏平,桑野良三
Organizer
第40回新潟神経学夏期セミナー
Place of Presentation
新潟
Year and Date
2010-08-06
Related Report
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[Presentation] R. Gene expression profiling of postmortem brain tissues with Alzheimer's disease2010
Author(s)
Miyashita A, Saito Y, Hatsuta H, Tsukie T, Kakita A, Iijima R, Ogishima S, Tanaka H, Takahashi H, Murayama S, Ihara Y, Kuwano
Organizer
Alzheimer's Association International Conference 2010
Place of Presentation
Hawaii
Year and Date
2010-07-11
Related Report
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[Presentation] アルツハイマー病脳組織におけるSORL1の遺伝子発現解析2010
Author(s)
温雅楠,宮下哲典,月江珠緒,齋藤祐子,初田裕幸,村山繁雄,柿田明美,高橋均,北村信隆,赤澤宏平,井原康夫,桑野良三
Organizer
第29回日本認知症学会
Place of Presentation
名古屋
Related Report
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[Presentation] 後部帯状回と楔前部におけるアミロイドβ沈着2010
Author(s)
初田裕幸,齋藤祐子,伊藤慎治,杉山美紀子,舟辺さやか,新井冨生,沢辺元司,金丸和富,石井賢二,宮下哲典,桑野良三,村山繁雄
Organizer
第29回日本認知症学会
Place of Presentation
名古屋
Related Report
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