NKG2D ligand expression and mechanism of immune escape from NKG2D-mediated surveillance in human inflammatory disease

• Project/Area Number: 22790336
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Chiba University
• Principal Investigator: FUGO Kazunori 千葉大学, 大学院・医学研究院, 助教 (20431306)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: NKG2D / 活性化リガンド / 炎症性疾患 / 免疫監視

Research Abstract

To understand the correlation between the expression profile of NKG2D ligands and various disorders in human, Immunohistochemical analyses were performed on human tissue specimens from several types of epithelial neoplasms and inflammatory disorders. Tissue-specificity concerning ligand expression patterns in epithelial neoplasms may be able to classify into at least three groups. Moreover, tissue-specificity concerning ligand dexpressin patterns in inflammatory disorders including autoimmune diseases may be similar with the tendency in the epithelial neoplasms.

Research Products

• [Journal Article] Involvement of an NKG2D Ligand H60c in Epidermal Dendritic T Cell-Mediated Wound Repair (2012)
  • Author(s): Yoshida S, Mohamed RH, Kajikawa M, Koizumi J, Tanaka M, Fugo K, Otsuka N, Maenaka K, Yagita H, Chiba H, Kasahara M
  • Journal Title: J Immunol Volume: 188(8) Pages: 3972-3979
  • Peer Reviewed
• [Journal Article] Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution (2010)
  • Author(s): Kondo M, Maruoka T, Otsuka N, Kasamatsu J, Fugo K, Hanzawa N, Kasahara M
  • Journal Title: Immunogenetics Volume: 62(7) Pages: 441-450
  • Peer Reviewed
• [Journal Article] Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution. (2010)
  • Author(s): Mizuho Kondo
  • Journal Title: Immunogenetics Volume: 62(7) Pages: 441-450
  • Peer Reviewed
• [Journal Article] Identification of a third variable lymphocyte receptor in the lamprey. (2010)
  • Author(s): Jun Kasamatsu
  • Journal Title: Proc Natl Acad Sci USA. Volume: 107(32) Pages: 14304-14308
  • Peer Reviewed
• [Presentation] NKG2Dリガンドの創傷治癒における役割の解析.MHC : Major Histocompatibility Complex (2011)
  • Author(s): 笠原正典, Mohamed Rania, 小泉潤, 富居一範, 大塚紀幸, 吉田繁
  • Organizer: 第20回日本組織適合性学会
  • Place of Presentation: 三島市
  • Year and Date: 2011-08-28
• [Presentation] ヒトNKG2Dリガンドの組織発現に関する免疫組織化学検討 (2011)
  • Author(s): 藤田裕美, 須藤洋一, 畑中豊, 富居一範, 大塚紀幸, 松野吉宏, 笠原正典
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2011-04-28
• [Presentation] 体表組織におけるナチュラルキラー細胞活性化リガンドH60cの役割 (2011)
  • Author(s): 吉田繁, 小泉潤, 富居一範, 近藤瑞穂, 大塚紀幸, 笠原正典
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2011-04-28
• [Presentation] 近交系マウスにおけるNKG2Dリガンド遺伝子のコピー数多型 (2010)
  • Author(s): 富居一範
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京・京王プラザホテル
  • Year and Date: 2010-04-27
• [Presentation] 粘膜免疫におけるナチュラルキラー細胞活性化リガンドH60cの役割 (2010)
  • Author(s): 吉田繁
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京・京王プラザホテル
  • Year and Date: 2010-04-27