| Project/Area Number |
22790337
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Tohoku University |
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Principal Investigator |
MIKI Yasuhiro 東北大学, 大学院・歯学研究科, 助教 (50451521)
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| Research Collaborator |
ABE Keiko 埼玉医科大学, 医学部, 講師 (80455782)
SUZUKI Takashi 東北大学, 大学院・医学系研究科, 教授 (10261629)
SASANO Hironobu 東北大学, 大学院・医学系研究科, 教授 (50187142)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 肺線維症 / 間質性肺炎 / エストロゲン / aromatase |
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| Research Abstract |
This is the first study to demonstrate tissue concentration of estrogen in human interstitial pneumonia (IP)/lung fibrosis tissues. Results from this study suggest that estradiol concentration in IP tissue is increased by aromatase, which is located in alveolar epithelial cells. In the result of mice model, expression level of phosphodiesterase mRNA in lung tissue was increased through the androgen signal. These results all suggest that sex steroid hormones, estrogen and androgen may play an important role in the development of IP.
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