Clinical relevance of cagPAI intactness in Helicobacter pylori isolates from Vietnam

• Project/Area Number: 22790348
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Oita University
• Principal Investigator: UCHIDA Tomohisa 大分大学, 医学部, 助教 (70381035)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 消化器 / 唾液腺 / ヘリコバクター・ピロリ / cagPAI遺伝子 / 胃炎 / 国際情報交換 / ベトナム / cagPAI / 胃がん / 病原因子

Research Abstract

The purpose of this paper is to investigate the relationship between clinical outcome and the intactness of cagPAI in Helicobacter pylori strains from Vietnam. H. pylori strains with internal deletion within cagPAI are less virulent and, thus, less likely to be associated with severe clinical outcomes.

Research Products

• [Journal Article] Impact of Helicobacter pylori CagA diversity on gastric mucosal damage : an immunohistochemical study of East-Asian-type CagA (2011)
  • Author(s): Takashi Abe
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 26 Issue: 4 Pages: 688-693
  • DOI: 10.1111/j.1440-1746.2010.06565.x
  • Peer Reviewed
• [Journal Article] The origin of non-H.pylori-related positive Giemsa staining in human gastric biopsy specimens : A prospective study (2011)
  • Author(s): Seo, T.H.Lee, S.Y.Uchida, T., et al., 全6名
  • Journal Title: Dig Liver Dis Volume: 43 Issue: 1 Pages: 41-113
  • DOI: 10.1016/j.dld.2010.04.006
  • Peer Reviewed
• [Journal Article] Helicobacter pylori infection and gastroduodenal diseases in Vietnam : a cross-sectional, hospital-based study (2010)
  • Author(s): Nguyen, T. L., Uchida, T., and Moriyama, M.(17人中2番目)
  • Journal Title: BMC gastroenterology Volume: 10 Pages: 114-114
  • Peer Reviewed
• [Journal Article] Clinical relevance of cagPAI intactness in Helicobacter pylori isolates from Vietnam (2010)
  • Author(s): Nguyen, L. T., Uchida, T., and Moriyama, M.(16人中2番目)
  • Journal Title: Eur J Clin Microbiol Infect Dis Volume: 29 Pages: 651-660
  • Peer Reviewed
• [Journal Article] Evaluation of rapid urine test for the detection of Helicobacter pylori infection in the Vietnamese population (2010)
  • Author(s): Nguyen, L. T., Uchida, T., and Moriyama, M.(15人中2番目)
  • Journal Title: Digestive diseases and sciences Volume: 55 Pages: 89-93
  • Peer Reviewed
• [Journal Article] Helicobacter pylori dupA gene is not associated with clinical outcomes in the Japanese population (2010)
  • Author(s): Nguyen, L. T., Uchida, T., and Moriyama, M.(9人中2番目)
  • Journal Title: Clin Microbiol Infect Volume: 16 Pages: 1264-1269
  • Peer Reviewed
• [Journal Article] Helicobacter pylori infection and gastroduodenal diseases in Vietnam : across-sectional, hospital-based study (2010)
  • Author(s): Nguyen, T.L., Uchida, T., Tsukamoto, Y., Trinh, D.T., Ta, L., Mai, B.H., Le, S.H., Thai, K.D., Ho, D.D., et al.
  • Journal Title: BMC Gastroenterol Volume: 10 Pages: 114-120
  • Peer Reviewed
• [Journal Article] Evaluation of rapid urine test for the detection of Helicobacter pylori infection in the Vietnamese population (2010)
  • Author(s): Nguyen, L.T., Uchida, T., Tsukamoto, Y., Trinh, T.D., Ta, L., Ho, D.Q., Matsuhisa, T., Uchida, M., et al
  • Journal Title: Dig Dis Sci Volume: 55 Pages: 89-93
  • Peer Reviewed
• [Presentation] Helicobacter pylori infection and gastroduodenal diseases in Vietnam (2011)
  • Organizer: 日韓ヘリコバクターカンファレンス
  • Place of Presentation: 韓国ソウル
  • Year and Date: 2011-09-28
• [Presentation] Evaluation of diagnostic tests for H.pylori infection in the Bhutanese population (2011)
  • Author(s): T Uchida, R.Vilaichone, L.Tshering, T.Fujioka, Y.Yamaoka
  • Organizer: Annual meeting of European Helicobacter Study Group
  • Place of Presentation: ダブリン(アイルランド)
  • Year and Date: 2011-09-12
• [Presentation] 免疫組織化学を用いたCagA多型性の検討と胃発癌との関連 (2010)
  • Author(s): 安部高志, 兒玉雅明, 沖本忠義, 藤岡利生, 内田智久, 守山正胤
  • Organizer: 日本消化器病学会
  • Place of Presentation: 新潟
  • Year and Date: 2010-04-23