Biological implication and clinical application for novel thyroid cancer specific biomarker

• Project/Area Number: 22790350
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Tokai University
• Principal Investigator: KIKUCHI Tomoki 東海大学, 医学部, 助教 (50404588)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 甲状腺乳頭癌 / SNX5 / caspase-2

Research Abstract

Immunohistochemical analysis with an SNX5-specific mAb established in this study consistently demonstrated the preferential expression of SNX5 in Papillary thyroid carcinoma cell. More interestingly, epithelial cells expressing excess SNX5 showed high levels of Caspase-2. Collectively further investigations focusing on the unique modality of SNX5 could clarify its unidentified mechanism and improve our understanding of the tumor cell biology of thyroid gland malignancies

Research Products

• [Journal Article] Sorting Nexin 5 of a New Diagnostic Marker of Papillary Thyroid Carcinoma Regulates Caspase-2 (2012)
  • Author(s): Ara S,Kikuchi T,Matsumiya H,Kojima T,Kubo T, Ye RC, Sato A, Kon SI, Honma T,Asakura K, Hasegawa T, Himi T,Sato N, Ichimiya S.
  • Journal Title: Cancer Science Volume: 103 Issue: 7 Pages: 1356-62
  • DOI: 10.1111/j.1349-7006.2012.02296.x
  • Peer Reviewed
• [Journal Article] Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help. (2011)
  • Author(s): Tsutomu Nagashima
  • Journal Title: American journal of pathology Volume: 178 Pages: 222-232
  • Peer Reviewed
• [Journal Article] 偽血管腔構造が特徴的な皮膚髄膜腫 (2010)
  • Author(s): 外岡暁子
  • Journal Title: 診断病理 Volume: 27 Pages: 123-127
  • Peer Reviewed
• [Journal Article] 若年成人女性の骨盤腔内に発生した胎児型横紋筋肉腫、紡錘形細胞亜型の1例 (2010)
  • Author(s): 計良淑子
  • Journal Title: 診断病理 Volume: 27 Pages: 36-39
  • Peer Reviewed
• [Presentation] 第8回日本病理学会カンファレンス2011松本 (2013)
  • Author(s): 荒志保子
  • Organizer: ホテルブエナビスタ
  • Place of Presentation: 松本
  • Year and Date: 2013-08-03
• [Presentation] 甲状腺乳頭癌におけるSNXファミリーの機能解析 (2013)
  • Author(s): 荒志保子
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2013-08-03
• [Presentation] 甲状腺乳頭癌におけるSNXファミリー分子発現の検討 (2013)
  • Author(s): 荒志保子
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2013-04-30
• [Presentation] 新たな甲状腺乳頭癌特異的バイオマーカーSNX5の意義とその臨床応用 (2012)
  • Author(s): 荒志保子
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2012-04-28
• [Presentation] 甲状腺乳頭癌におけるSNXファミリー分子発現の検討 (2011)
  • Author(s): 荒志保子
  • Organizer: 第8回日本病理学会カンファレンス2011松本
  • Place of Presentation: ホテルブエナビスタ(松本)
  • Year and Date: 2011-08-06
• [Presentation] 甲状腺乳頭癌におけるSNXファミリー分子発現の検討 (2011)
  • Author(s): 荒志保子
  • Organizer: 第100回日本病理学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-04-30