Partial tandem duplication in childhood acute myeloblastic leukemia and molecular targeted therapy
Project/Area Number |
22790355
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Human pathology
|
Research Institution | Keio University |
Principal Investigator |
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 病理学 / 癌 / 遺伝子 / 白血病 |
Research Abstract |
We established a suppression system of MLL partial tandem duplication(MLL-PTD) gene using siRNA in childhood acute myeloblastic leulkemia cell line with MLL-PTD, KOPM-88. The siRNA repressed the growth of KOPM-88 cells by 20%. Furthermore, we confirmed anti-tumor effect of anti-CD26 monoclonal antibody against CD26 positive malignant hematopoietic tumor cell lines.
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Report
(3 results)
Research Products
(6 results)