Partial tandem duplication in childhood acute myeloblastic leukemia and molecular targeted therapy

• Project/Area Number: 22790355
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Keio University
• Principal Investigator: HAYASHI Mutsumi 慶應義塾大学, 医学部, 特任助教 (60327575)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 病理学 / 癌 / 遺伝子 / 白血病

Research Abstract

We established a suppression system of MLL partial tandem duplication(MLL-PTD) gene using siRNA in childhood acute myeloblastic leulkemia cell line with MLL-PTD, KOPM-88. The siRNA repressed the growth of KOPM-88 cells by 20%. Furthermore, we confirmed anti-tumor effect of anti-CD26 monoclonal antibody against CD26 positive malignant hematopoietic tumor cell lines.

Research Products

• [Presentation] ヒト化抗CD26モノクローナル抗体による中皮腫の抗体療法の分子機構:細胞周期調節による抗腫瘍作用 (2012)
  • Author(s): 林睦、山田幸司、坂元亨宇、森本幾夫、山田健人
  • Organizer: 第101回病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-28
• [Presentation] ヒト化CD26モノクローナル抗体による中皮腫の抗体療法の分子機構: CD26核移行と転写調節を介して (2012)
  • Author(s): 山田幸司、林睦、坂元亨宇、森本幾夫、山田健人
  • Organizer: 第101回病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-28
• [Presentation] CD26と抗CD26抗体の細胞膜-核間輸送機構とその機能 (2010)
  • Author(s): 山田幸司、林睦、坂元亨宇、森本幾夫、山田健人
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] Humanized anti-CD26 monoclonal antibody therapy against mesothelioma and its molecular mechanisms (2010)
  • Author(s): Mutsumi Hayashi, Kohji Yamada, Wenlin Du, Michiie Sakamoto, Chikao Morimoto, Taketo Yamada
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] Humanized anti-CD26 monoclonal antibody therapy against mesothelioma and its molecular mechanisms. (2010)
  • Author(s): Mutsumi Hayashi, Kohji Yamada, Wenlin Du, Michiie Sakamoto, Chikao Morimoto, Taketo Yamada
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] ヒト化抗CD26モノクローナル抗体を用いた悪性中皮腫の新規治療法の基礎的検討 (2010)
  • Author(s): 林睦、山田幸司、杜ぶん林、坂元亨宇、山田健人
  • Organizer: 第99回病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-28