The relationship between the hetelogenity of HER2 gene over-expression and polysomy 17

Research Project

Project/Area Number	22790357
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Human pathology
Research Institution	Tokai University
Principal Investigator	KUMAKI Nobue 東海大学, 医学部, 講師 (90366021)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	泌尿生殖器・内分泌 / 乳癌 / HER2遺伝子 / ポリソミー17 / HER2 / polysomy 17 / Dual ISH法
Research Abstract	HER2 gene over-expression greatly affects breast cancer prognosis and the trastuzumab treatment. The aim of this study was to clarify the relationship between the heterogeneity of HER2 gene over-expression and polysomy 17 using DISH(Dual color in situ hybridization) method. In some cases, HER2 gene expression status and centromere 17 copy number differed between invasive part and intraductal part of breast cancer. This result suggests the possibility that the difference involves in stromal invasion of cancer cells. It is thought that polysomy 17 occasionally influences HER2 status assessment, therefore the selecting the method by which HER2 status is evaluated needs to be done in light of any relationships among these factors and therapeutic effects of trastuzumab.

Report

(3 results)