| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Research Abstract |
Using early colorectal carcinoma cases,histopathological observations and immunohistochemistry for LYVE-1, von Willebrand factor, MMP-7, CXCL12, and ANGPTL4 were conducted. Relationships between LN metastasis and growth pattern, status of muscularis mucosae, depth of cancer invasion, histopathological type, tumour budding, neutrophil infiltration in cancer cells (NIC), fibrotic cancer-stroma type, Crohn’s-like lymphoid reaction, microscopic abscess formation, lymphatic invasion, the expression of MMP-7, CXCL12 and ANGPTL4 in cancer cells at the invasive front were determined. By multivariate analysis,lymphatic invasion, NIC, and MMP-7 expression at the invasive front were independent predictors of LN metastasis.
|
