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Analysis of lymphatic metastasis in early gastrointestinal carcinoma

Research Project

Project/Area Number 22790360
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionToho University

Principal Investigator

FUKASAWA Yuri  東邦大学, 医学部, 講師 (90392331)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords消化器 / 癌 / 病理学 / 消化器がん / リンパ節転移
Research Abstract

Using early colorectal carcinoma cases,histopathological observations and immunohistochemistry for LYVE-1, von Willebrand factor, MMP-7, CXCL12, and ANGPTL4 were conducted. Relationships between LN metastasis and growth pattern, status of muscularis mucosae, depth of cancer invasion, histopathological type, tumour budding, neutrophil infiltration in cancer cells (NIC), fibrotic cancer-stroma type, Crohn’s-like lymphoid reaction, microscopic abscess formation, lymphatic invasion, the expression of MMP-7, CXCL12 and ANGPTL4 in cancer cells at the invasive front were determined. By multivariate analysis,lymphatic invasion, NIC, and MMP-7 expression at the invasive front were independent predictors of LN metastasis.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (4 results)

All 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Histopathological predictors of regional lymph node metastasis at the invasive front in early colorectal cancer2011

    • Author(s)
      Akishima-Fukasawa Y, Ishikawa Y, Akasaka Y
    • Journal Title

      Histopathology

      Volume: 59巻 Issue: 3 Pages: 470-481

    • DOI

      10.1111/j.1365-2559.2011.03964.x

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 早期大腸がんにおけるリンパ節転移規定因子の解析.2011

    • Author(s)
      深澤 由里, 石井 隆雅.
    • Organizer
      東邦医学会総会.
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 早期結腸癌におけるリンパ節転移の組織学的規定因子2010

    • Author(s)
      深澤由里
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2010-04-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 早期結腸癌におけるリンパ節転移の組織学的規定因子.2010

    • Author(s)
      深澤 由里, 石川 由起雄, 赤坂 喜清, 宇月 美和, 下川 伶子, 向井 清, 木口 英子, 藤原 美恵子, 鈴木 高祐, 一瀬 晃洋, 緒方 謙太郎, 新野 史, 杉浦 仁, 石井壽晴.
    • Organizer
      第99回日本病理学総会.
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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