Analysis of lymphatic metastasis in early gastrointestinal carcinoma

• Project/Area Number: 22790360
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Toho University
• Principal Investigator: FUKASAWA Yuri 東邦大学, 医学部, 講師 (90392331)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 消化器 / 癌 / 病理学 / 消化器がん / リンパ節転移

Research Abstract

Using early colorectal carcinoma cases,histopathological observations and immunohistochemistry for LYVE-1, von Willebrand factor, MMP-7, CXCL12, and ANGPTL4 were conducted. Relationships between LN metastasis and growth pattern, status of muscularis mucosae, depth of cancer invasion, histopathological type, tumour budding, neutrophil infiltration in cancer cells (NIC), fibrotic cancer-stroma type, Crohn’s-like lymphoid reaction, microscopic abscess formation, lymphatic invasion, the expression of MMP-7, CXCL12 and ANGPTL4 in cancer cells at the invasive front were determined. By multivariate analysis,lymphatic invasion, NIC, and MMP-7 expression at the invasive front were independent predictors of LN metastasis.

Research Products

• [Journal Article] Histopathological predictors of regional lymph node metastasis at the invasive front in early colorectal cancer (2011)
  • Author(s): Akishima-Fukasawa Y, Ishikawa Y, Akasaka Y
  • Journal Title: Histopathology Volume: 59巻 Issue: 3 Pages: 470-481
  • DOI: 10.1111/j.1365-2559.2011.03964.x
  • Peer Reviewed
• [Presentation] 早期大腸がんにおけるリンパ節転移規定因子の解析. (2011)
  • Author(s): 深澤 由里, 石井 隆雅.
  • Organizer: 東邦医学会総会.
  • Place of Presentation: 東京
• [Presentation] 早期結腸癌におけるリンパ節転移の組織学的規定因子 (2010)
  • Author(s): 深澤由里
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2010-04-27
• [Presentation] 早期結腸癌におけるリンパ節転移の組織学的規定因子. (2010)
  • Author(s): 深澤 由里, 石川 由起雄, 赤坂 喜清, 宇月 美和, 下川 伶子, 向井 清, 木口 英子, 藤原 美恵子, 鈴木 高祐, 一瀬 晃洋, 緒方 謙太郎, 新野 史, 杉浦 仁, 石井壽晴.
  • Organizer: 第99回日本病理学総会.
  • Place of Presentation: 東京