Analysis of CTGF,the new candidate of the tumor suppressor gene in ovarian cancer, for personalized anti-cancer therapy
| Project/Area Number |
22790364
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | National Defense Medical College |
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Principal Investigator |
KIKUCHI Ryoko 防衛医科大学校, 医学教育部医学科専門課程, 助教 (80535063)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 分子病理 / 卵巣癌 / CTGF / 抗癌剤感受性 / 低酸素 / 蛍光標識二次元電気泳動法 / CTGF遺伝子 / 抗癌剤 / 化学療法の個別化 |
|---|
| Research Abstract |
Knockdown of CTGF with specific small interfering RNAs in OVISE cells, the ovarian clear cell carcinoma cell line, and in OVSAHO cells, the ovarian serous carcinoma cell line enhanced resistance to apoptosis on exposure to paclitaxel, but not enhanced resistance to apotosis on exposure to carboplatin, cisplatin and doxorubicin.
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Report
(4 results)
Research Products
(11 results)
