Alteration of cancer and microenvironment in serosal invasion area
Project/Area Number |
22790365
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Human pathology
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Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
Principal Investigator |
KOJIMA Motohiro 独立行政法人国立がん研究センター, 臨床開発センター, 室長 (30338470)
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 病理学 / 癌 |
Research Abstract |
We showed that tumor invasion beyond the peritoneal elastic lamina(elastic laminal invasion : ELI) is strong prognostic factor which influence on the stratification pT factor in TNM classification. We found that fibrosis and tumor budding are histological features of ELI. To know biological feature of the fibroblast in serosal area, we established primary culture of fibroblast from serosal and submucosal area of human sigmoid colon. From the result of co-injection of fibroblast and colon cancer cells, we demonstrate that fibroblast from serosal area actively promote cancer growth and metastasis.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] In response2011
Author(s)
Motohiro Kojima
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Journal Title
American Journal of Surgical Pathology
Volume: 35(3)
Pages: 468-469
Related Report
Peer Reviewed
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