| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
We showed that tumor invasion beyond the peritoneal elastic lamina(elastic laminal invasion : ELI) is strong prognostic factor which influence on the stratification pT factor in TNM classification. We found that fibrosis and tumor budding are histological features of ELI. To know biological feature of the fibroblast in serosal area, we established primary culture of fibroblast from serosal and submucosal area of human sigmoid colon. From the result of co-injection of fibroblast and colon cancer cells, we demonstrate that fibroblast from serosal area actively promote cancer growth and metastasis.
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