Functional conversion of tumor-supporting myeloid cells to tumoricidal effectors by dsRNA adjuvant
| Project/Area Number |
22790371
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
SHIME Hiroaki 北海道大学, 大学院・医学研究科, 助教 (70372133)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 癌 / アジュバント / TLR3 / マクロファージ / 癌免疫療法 / 2本鎖RNA / TICAM-1 / TRIF / 抗腫瘍免疫 / 自然免疫 / TLR / 腫瘍免疫 / 免疫抑制 / MDSC / poly I:C / 二本鎖RNA |
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| Research Abstract |
In many cancer patients, immune system is subverted by immunosuppressive cells as well as tumor-derived factors, which contributes to tumor progression. Tumor-associated macrophages with immunosuppressive, M2-like phenotype support the tumor growth by several mechanisms. Here, we show that double-stranded RNA(dsRNA) adjuvant induces growth retardation of 3LL tumor by converting tumor-supporting macrophages to tumoricidal effectors through the activation of TLR3-TICAM-1 signaling pathway
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Report
(3 results)
Research Products
(45 results)
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[Journal Article] Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR22011
Author(s)
Sawahata, R., Shime, H., Yamazaki, S., Inoue, N., Akazawa, T., Fujimoto, Y., Fukase, K., Matsumoto, M. and Seya, T.
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Journal Title
Microbes and Infection
Volume: 13
Issue: 4
Pages: 350-358
DOI
NAID
Related Report
Peer Reviewed
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